Melanin biosynthesis in Cryptococcus neoformans

被引：104
作者：
Williamson, PR
Wakamatsu, K
Ito, S
机构：
[1] Univ Illinois, Coll Med, Div Infect Dis, Chicago, IL 60612 USA
[2] Fujita Hlth Univ, Sch Hlth Sci, Aichi 4701192, Japan
来源：
JOURNAL OF BACTERIOLOGY | 1998年 / 180卷 / 06期
关键词：
D O I：
10.1128/JB.180.6.1570-1572.1998
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Pigment production by Cryptococcus neoformans is virulence associated. Dopamine-and 3,4 dihydroxyphenylalanine-melanin products were identified after acidic permanganate oxidation, alkaline hydrogen peroxide oxidation, or hydrolysis with hydriodic acid. These data provide direct chemical evidence for the formation of eumelanin Polymers by catecholamine oxidation by laccase alone followed by oxidative coupling of dihydroxyindole.
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页码：1570 / 1572
页数：3
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