Molecular Pathophysiology of Gout

被引：229

作者：

Desai, Jyaysi ^{[1
]}

Steiger, Stefanie ^{[1
]}

Anders, Hans-Joachim ^{[1
]}

机构：

[1] Klinikum Univ Munchen, Med Klin & Poliklin 4, Munich, Germany

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 08期

关键词：

INTERLEUKIN-1 RECEPTOR ANTAGONIST; NEUTROPHIL EXTRACELLULAR TRAPS; INDUCED ACUTE-INFLAMMATION; OF-RHEUMATOLOGY GUIDELINES; URIC-ACID CRYSTALS; TOLL-LIKE RECEPTOR; NF-KAPPA-B; CELL-DEATH; NEGATIVE REGULATION; NLRP3; INFLAMMASOME;

D O I：

10.1016/j.molmed.2017.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three contradictory clinical presentations of gout have puzzled clinicians and basic scientists for some time: first, the crescendo of sterile inflammation in acute gouty arthritis; second, its spontaneous resolution, despite monosodium urate (MSU) crystal persistence in the synovium; and third, immune anergy to MSU crystal masses observed in tophaceous or visceral gout. Here, we provide an update on the molecular pathophysiology of these gout manifestations, namely, how MSU crystals can trigger the auto-amplification loop of necroinflammation underlying the crescendo of acute gouty arthritis. We also discuss new findings, such as how aggregating neutrophil extracellular traps (NETs) might drive the resolution of arthritis and how these structures, together with granuloma formation, might support immune anergy, but yet promote tissue damage and remodeling during tophaceous gout.

引用

页码：756 / 768

页数：13

共 107 条

[1] Gout - a guide for the general and acute physicians [J].

Abhishek, Abhishek ;

Roddy, Edward ;

Doherty, Michael .

CLINICAL MEDICINE, 2017, 17 (01) :54-59

[2] NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury [J].

Almyroudis, Nikolaos G. ;

Grimm, Melissa J. ;

Davidson, Bruce A. ;

Roehm, Marc ;

Urban, Constantin F. ;

Segal, Brahm H. .

FRONTIERS IN IMMUNOLOGY, 2013, 4

[3] Efficacy of Anakinra for Various Types of Crystal-Induced Arthritis in Complex Hospitalized Patients: A Case Series and Review of the Literature [J].

Aouba, A. ;

Deshayes, S. ;

Frenzel, L. ;

Decottignies, A. ;

Pressiat, C. ;

Bienvenu, B. ;

Boue, F. ;

Damaj, G. ;

Hermine, O. ;

Georgin-Lavialle, S. .

MEDIATORS OF INFLAMMATION, 2015, 2015 :1-7

[4] Molecular circuits of resolution: Formation and actions of resolvins and protectins [J].

Bannenberg, GL ;

Chiang, N ;

Ariel, A ;

Arita, M ;

Tjonahen, E ;

Gotlinger, KH ;

Hong, S ;

Serhan, CN .

JOURNAL OF IMMUNOLOGY, 2005, 174 (07) :4345-4355

[5] Specialised pro-resolving mediators of inflammation in inflammatory arthritis [J].

Barden, Anne E. ;

Moghaddami, Mahin ;

Mas, Emilie ;

Phillips, Michael ;

Cleland, Leslie G. ;

Mori, Trevor A. .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2016, 107 :24-29

[6] Pyrin-only protein 2 modulates NFκB and disrupts ASC:CLR interactions [J].

Bedoya, Felipe ;

Sandler, Laurel L. ;

Harton, Jonathan A. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3837-3845

[7] Endotoxin tolerance: new mechanisms, molecules and clinical significance [J].

Biswas, Subhra K. ;

Lopez-Collazo, Eduardo .

TRENDS IN IMMUNOLOGY, 2009, 30 (10) :475-487

[8] Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis [J].

Chae, JJ ;

Komarow, HD ;

Cheng, J ;

Wood, G ;

Raben, N ;

Liu, PP ;

Kastner, DL .

MOLECULAR CELL, 2003, 11 (03) :591-604

[9] Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFβ1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3 [J].

Chen, Yu-Hsuan ;

Hsieh, Song-Chou ;

Chen, Wei-Yu ;

Li, Ko-Jen ;

Wu, Cheng-Han ;

Wu, Po-Chang ;

Tsai, Chang-Youh ;

Yu, Chia-Li .

ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (09) :1655-1663

[10] The Gouty Tophus: a Review [J].

Chhana, Ashika ;

Dalbeth, Nicola .

CURRENT RHEUMATOLOGY REPORTS, 2015, 17 (03)

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