Role of the brain heme oxygenase-carbon monoxide pathway in stress fever in rats

被引：17
作者：
Steiner, AA [1 ]
Reste, G
Branco, LGS
机构：
[1] Med Sch Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP, Brazil
[2] St Joseph Hosp & Med Ctr, Phoenix, AZ USA
[3] Dent Sch Ribeirao Preto, Dept Morphol Stomatol & Physiol, Ribeirao Preto, SP, Brazil
来源：
NEUROSCIENCE LETTERS | 2003年 / 341卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
body temperature; hyperthermia; anxiety; restraint; central nervous system; metaloporphyrins;
D O I：
10.1016/S0304-3940(03)00197-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study was aimed at testing the hypothesis that the brain heme oxygenase (HO)-carbon monoxide (CO) pathway plays a role in stress fever. To this end, the effect of the HO inhibitor, zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG), on restraint-induced fever was tested. Intracerebroventricular ZnDPBG (200 nmol) did not affect the body core temperature of unrestrained rats, but markedly attenuated restraint-induced fever. However, at the same dose, intraperitoneal ZnDPBG did not affect the febrile response to restraint. Taken together, these results indicate that the brain HO-CO pathway plays a major role in the genesis of stress fever in rats. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：193 / 196
页数：4
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