MECHANISMS OF DISEASE Graves' Ophthalmopathy

被引：1067
作者：
Bahn, Rebecca S. [1 ]
机构：
[1] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 362卷 / 08期
关键词：
THYROID-ASSOCIATED OPHTHALMOPATHY; HUMAN ORBITAL FIBROBLASTS; THYROTROPIN RECEPTOR EXPRESSION; FACTOR-I RECEPTOR; T-CELL-ACTIVATION; RHEUMATOID-ARTHRITIS; ADIPOSE-TISSUE; PREADIPOCYTE FIBROBLASTS; CONNECTIVE-TISSUE; GLYCOSAMINOGLYCAN PRODUCTION;
D O I：
10.1056/NEJMra0905750
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This article reviews the mechanisms that lead to the development of Graves' ophthalmopathy. A central feature in its development is autoimmunity that involves not only T cells, B cells, and macrophages but also fibroblasts and adipose tissue within the orbit. Intraorbital cytokine-mediated inflammation also has a prominent role. These recent findings suggest new ways of treating this debilitating disease. Copyright © 2010 Massachusetts Medical Society.
引用
收藏
页码：726 / 738
页数：13
相关论文
共 122 条
  • [31] Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies
    El Fassi, Daniel
    Banga, J. Paul
    Gilbert, Jacqueline A.
    Padoa, Carolyn
    Hegedus, Laszlo
    Nielsen, Claus H.
    [J]. CLINICAL IMMUNOLOGY, 2009, 130 (03) : 252 - 258
  • [32] THYROTROPIN RECEPTOR IN NONTHYROID TISSUES
    ENDO, T
    OHNO, M
    KOTANI, S
    GUNJI, K
    ONAYA, T
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 190 (03) : 774 - 779
  • [33] ENZMANN DR, 1979, J COMPUT ASSIST TOMO, V3, P815
  • [34] Pretibial myxedema - Pathophysiology and treatment options
    Fatourechi, V
    [J]. AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2005, 6 (05) : 295 - 309
  • [35] Development of anti-TNF therapy for rheumatoid arthritis
    Feldmann, M
    [J]. NATURE REVIEWS IMMUNOLOGY, 2002, 2 (05) : 364 - 371
  • [36] Design of effective immunotherapy for human autoimmunity
    Feldmann, M
    Steinman, L
    [J]. NATURE, 2005, 435 (7042) : 612 - 619
  • [37] Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy
    Feldon, SE
    Park, DJJ
    O'Loughlin, CW
    Nguyen, VT
    Landskroner-Eiger, S
    Chang, D
    Thatcher, TH
    Phipps, RP
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (11) : 3913 - 3921
  • [38] Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes
    Feldon, Steven E.
    O'Loughlin, Charles W.
    Ray, Denise M.
    Landskroner-Eiger, Shira
    Seweryniak, Kathryn E.
    Phipps, Richard P.
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2006, 169 (04) : 1183 - 1193
  • [39] EXPRESSION OF THYROTROPIN-RECEPTOR MESSENGER-RNA IN HEALTHY AND GRAVES-DISEASE RETRO-ORBITAL TISSUE
    FELICIELLO, A
    PORCELLINI, A
    CIULLO, I
    BONAVOLONTA, G
    AVVEDIMENTO, EV
    FENZI, G
    [J]. LANCET, 1993, 342 (8867) : 337 - 338
  • [40] FORBES G, 1986, AM J NEURORADIOL, V7, P651
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