MECHANISMS OF DISEASE Graves' Ophthalmopathy

被引：1067
作者：
Bahn, Rebecca S. [1 ]
机构：
[1] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 362卷 / 08期
关键词：
THYROID-ASSOCIATED OPHTHALMOPATHY; HUMAN ORBITAL FIBROBLASTS; THYROTROPIN RECEPTOR EXPRESSION; FACTOR-I RECEPTOR; T-CELL-ACTIVATION; RHEUMATOID-ARTHRITIS; ADIPOSE-TISSUE; PREADIPOCYTE FIBROBLASTS; CONNECTIVE-TISSUE; GLYCOSAMINOGLYCAN PRODUCTION;
D O I：
10.1056/NEJMra0905750
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This article reviews the mechanisms that lead to the development of Graves' ophthalmopathy. A central feature in its development is autoimmunity that involves not only T cells, B cells, and macrophages but also fibroblasts and adipose tissue within the orbit. Intraorbital cytokine-mediated inflammation also has a prominent role. These recent findings suggest new ways of treating this debilitating disease. Copyright © 2010 Massachusetts Medical Society.
引用
收藏
页码：726 / 738
页数：13
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