Primary bilateral corneal nerve sheath neoplasm in a dog

被引：3

作者：

Leis, Marina L. ^{[1
]}

Salpeter, M. Elyse ^{[1
]}

Bauer, Bianca S. ^{[1
]}

Godson, Dale L. ^{[2
]}

Grahn, Bruce H. ^{[1
]}

机构：

[1] Univ Saskatchewan, Dept Small Anim Clin Sci, Western Coll Vet Med, 52 Campus Dr, Saskatoon, SK S7N 5B4, Canada

[2] Univ Saskatchewan, Western Coll Vet Med, Prairie Diagnost Serv, 52 Campus Dr, Saskatoon, SK S7N 5B4, Canada

来源：

VETERINARY OPHTHALMOLOGY | 2017年 / 20卷 / 04期

关键词：

canine; corneal neoplasia; electron microscopy; histopathology; immunohistochemistry; nerve sheath neoplasm; SQUAMOUS-CELL CARCINOMA; BLUE-EYED DOGS; CHOROIDAL SCHWANNOMA; UVEAL SCHWANNOMA; CASE SERIES; TUMOR; NEUROFIBROMA; MELANOMA; DIFFUSE; S-100;

D O I：

10.1111/vop.12398

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A 15-year-old, neutered male, Shih Tzu cross developed progressive corneal stromal thickening and vascularization of the right eye, and 5 months later, of the left eye. Both eyes became blind due to extensive corneal opacification and were enucleated. Light microscopic examination revealed a diffuse corneal infiltrate of neoplastic mesenchymal cells, and immunohistochemistry revealed diffuse cytoplasmic vimentin immunoreactivity and variable cytoplasmic and nuclear immunoreactivity for S100 in the neoplastic cells. Transmission electron microscopy revealed desmosomes between contiguous cells, thread-like cytoplasmic processes coated with basement membrane, extracellular bundles of collagen, and axonal degeneration consistent with features of a nerve sheath neoplasm. This is the first report of primary, bilateral corneal nerve sheath sarcoma in a canine.

引用

页码：365 / 371

页数：7

共 38 条

[1] ANGIOTENSIN CONVERTING ENZYME-SYSTEM IN THE NORMAL CANINE EYE - PHARMACOLOGICAL AND PHYSIOLOGICAL-ASPECTS [J].