Microwave-assisted synthesis and antibacterial evaluation of new derivatives of 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

被引：0

作者：

Ebrahimpour, Zahra ^{[1
]}

Shiri, Ali ^{[1
]}

Bakavoli, Mehdi ^{[1
]}

Seyedi, Seyed Mohammad ^{[1
]}

Bahreini, Masoumeh ^{[2
]}

Oroojalian, Fatemeh ^{[3
]}

机构：

[1] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad 917751436, Iran

[2] Ferdowsi Univ Mashhad, Dept Biol, Fac Sci, Mashhad 917751436, Iran

[3] Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Tehran 143951561, Iran

来源：

HETEROCYCLIC COMMUNICATIONS | 2016年 / 22卷 / 01期

关键词：

antibacterial; microwave; pyrazolo[3,4-d]pyrimidin-3-one; synthesis; BIOLOGICAL EVALUATION; INHIBITORS; DESIGN; POTENT; PYRAZOLOPYRIMIDINES; DOCKING;

D O I：

10.1515/hc-2015-0145

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of new 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones 4-6 starting with ethyl 4-hydroxy-2-methylthio-pyrimidine-5-carboxylate (1) under classical heating and microwave-induced conditions is reported. The antibacterial activities of the synthesized compounds were evaluated using chloramphenicol and streptomycin as reference drugs.

引用

页码：49 / 53

页数：5

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