Microwave-assisted synthesis and antibacterial evaluation of new derivatives of 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

被引：0
|
作者：
Ebrahimpour, Zahra [1 ]
Shiri, Ali [1 ]
Bakavoli, Mehdi [1 ]
Seyedi, Seyed Mohammad [1 ]
Bahreini, Masoumeh [2 ]
Oroojalian, Fatemeh [3 ]
机构：
[1] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad 917751436, Iran
[2] Ferdowsi Univ Mashhad, Dept Biol, Fac Sci, Mashhad 917751436, Iran
[3] Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Tehran 143951561, Iran
来源：
HETEROCYCLIC COMMUNICATIONS | 2016年 / 22卷 / 01期
关键词：
antibacterial; microwave; pyrazolo[3,4-d]pyrimidin-3-one; synthesis; BIOLOGICAL EVALUATION; INHIBITORS; DESIGN; POTENT; PYRAZOLOPYRIMIDINES; DOCKING;
D O I：
10.1515/hc-2015-0145
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of new 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones 4-6 starting with ethyl 4-hydroxy-2-methylthio-pyrimidine-5-carboxylate (1) under classical heating and microwave-induced conditions is reported. The antibacterial activities of the synthesized compounds were evaluated using chloramphenicol and streptomycin as reference drugs.
引用
收藏
页码：49 / 53
页数：5
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