The role of matricellular proteins and tissue stiffness in breast cancer: a systematic review

被引：12

作者：

Fiorino, Sirio ^{[1
]}

Di Saverio, Salomone ^{[2
]}

Leandri, Paolo ^{[1
]}

Tura, Andrea ^{[3
]}

Birtolo, Chiara ^{[4
]}

Silingardi, Mauro ^{[5
]}

de Biase, Dario ^{[6
]}

Avisar, Eli ^{[7
]}

机构：

[1] Maggiore Hosp, Local Hlth Unit Bologna, Internal Med Unit C, Bologna, Italy

[2] Cambridge Univ Hosp NHS Fdn Trust, Cambridge Colorectal Unit, Addenbrookes Hosp, Box 201,Cambridge Biomed Campus,Hills Rd, Cambridge CB2 0QQ, England

[3] CNR Inst Neurosci, Metab Unit, Padua, Italy

[4] Azienda USL Maggiore Hosp, Geriatr Unit, Largo Nigrisoli 3, Bologna, Italy

[5] Maggiore Hosp, Local Hlth Unit Bologna, Internal Med Unit A, Bologna, Italy

[6] Univ Bologna, Mol Pathol Unit, Dept Pharm & Biotechnol, Bologna, Italy

[7] Univ Miami, Miller Sch Med, Dept Surg, Div Surg Oncol, Miami, FL 33136 USA

来源：

FUTURE ONCOLOGY | 2018年 / 14卷 / 16期

关键词：

breast cancer; matricellular proteins; osteopontin; periostin; SPARC; stiffness; EXTRACELLULAR-MATRIX COMPONENTS; POTENTIAL CLINICAL-APPLICATIONS; MAMMOGRAPHIC DENSITY MEASURES; TENASCIN-C; COLLAGEN FIBRILLOGENESIS; PLASMINOGEN-ACTIVATOR; SPARC EXPRESSION; PROGNOSTIC VALUE; BIOMECHANICAL PROPERTIES; SUSCEPTIBILITY VARIANTS;

D O I：

10.2217/fon-2017-0510

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignancies consist not only of cancerous and nonmalignant cells, but also of additional elements, as extracellular matrix. The aim of this review is to summarize meta-analyses, describing breast tissue stiffness and risk of breast carcinoma (BC) assessing the potential relationship between matricellular proteins (MPs) and survival. A systematic computer-based search of published articles, according to PRISMA statement, was conducted through Ovid interface. Mammographic density and tissue stiffness are associated with the risk of BC development, suggesting that MPs may influence BC prognosis. No definitive conclusions are available and additional researches are required to definitively clarify the role of each MP, mammographic density and stiffness in BC development and the mechanisms involved in the onset of this malignancy.

引用

页码：1601 / 1627

页数：27

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