Gukulenins A and B, Cytotoxic Tetraterpenoids from the Marine Sponge Phorbas gukulensis

被引：25
|
作者：
Park, Su Young [1 ]
Choi, Hyukjae [2 ]
Hwang, Hoosang [2 ]
Kang, Heonjoong [2 ]
Rho, Jung-Rae [1 ]
机构：
[1] Kunsan Natl Univ, Dept Oceanog, Jeonbuk 673701, South Korea
[2] Seoul Natl Univ, Ctr Marine Nat Prod & Drug Discovery, Sch Earth & Environm Sci, Seoul 151747, South Korea
来源：
JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 04期
关键词：
D O I：
10.1021/np900606h
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Gukulenins A (1) and B (2), both having an unprecedented skeleton with a bis-tropolone moiety, were isolated from the Korean marine sponge Phorbas gukulensis. They exhibited significant cytotoxicity against human pharynx, stomach, colon, and renal cancer cell lines in the range 0.05-0.80 mu M.
引用
收藏
页码：734 / 737
页数：4
相关论文
共 50 条
  • [21] Koshikamide B, a cytotoxic peptide lactone from a marine sponge Theonella sp
    Araki, Takahiro
    Matsunaga, Shigeki
    Nakao, Yoichi
    Furihata, Kazuo
    West, Lyndon
    Faulkner, D. John
    Fusetani, Nobuhiro
    JOURNAL OF ORGANIC CHEMISTRY, 2008, 73 (20): : 7889 - 7894
  • [22] Absolute configuration of phorboxazoles A and B from the marine sponge, Phorbas sp .2. C43 and complete stereochemistry
    Molinski, TF
    TETRAHEDRON LETTERS, 1996, 37 (44) : 7879 - 7880
  • [23] PHORBAZOLES A-D, NOVEL CHLORINATED PHENYLPYRROLYLOXAZOLES FROM THE MARINE SPONGE PHORBAS AFF CLATHRATA
    RUDI, A
    STEIN, Z
    GREEN, S
    GOLDBERG, I
    KASHMAN, Y
    BENAYAHU, Y
    SCHLEYER, M
    TETRAHEDRON LETTERS, 1994, 35 (16) : 2589 - 2592
  • [24] Antibiofilm Activity of Phorbaketals from the Marine Sponge Phorbas sp. against Staphylococcus aureus
    Kim, Yong-Guy
    Lee, Jin-Hyung
    Lee, Sangbum
    Lee, Young-Kyung
    Hwang, Buyng Su
    Lee, Jintae
    MARINE DRUGS, 2021, 19 (06)
  • [25] Salicylihalamides A and B, novel cytotoxic macrolides from the marine sponge Haliclona sp.
    Erickson, KL
    Beutler, JA
    Cardellina, JH
    Boyd, MR
    JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (23): : 8188 - 8192
  • [26] Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge
    Hamada, Toshiyuki
    Matsunaga, Shigeki
    Fujiwara, Masako
    Fujita, Kenichi
    Hirota, Hiroshi
    Schmucki, Roland
    Guentert, Peter
    Fusetani, Nobuhiro
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (37) : 12941 - 12945
  • [27] Haligramides A and B, two new cytotoxic hexapeptides from the marine sponge Haliclona nigra
    Rashid, MA
    Gustafson, KR
    Boswell, JL
    Boyd, MR
    JOURNAL OF NATURAL PRODUCTS, 2000, 63 (07): : 956 - 959
  • [28] Eurysterols A and B, cytotoxic and antifungal steroidal sulfates from a marine sponge of the genus Euryspongia
    Boonlarppradab, Chollaratt
    Faulkner, D. John
    JOURNAL OF NATURAL PRODUCTS, 2007, 70 (05): : 846 - 848
  • [29] Bilosespens A and B:: Two novel cytotoxic sesterpenes from the marine sponge Dysidea cinerea
    Rudi, A
    Yosief, T
    Schleyer, M
    Kashman, Y
    ORGANIC LETTERS, 1999, 1 (03) : 471 - 472
  • [30] Haliclonacyclamines A and B, cytotoxic alkaloids from the tropical marine sponge Haliclona sp.
    Charan, RD
    Garson, MJ
    Brereton, IM
    Willis, AC
    Hooper, JNA
    TETRAHEDRON, 1996, 52 (27) : 9111 - 9120
12345