Cytotoxicity and Antimicrobial Activity of Nerium oleander Extracts

被引：20

作者：

El Sawi, Nagwa M. ^{[1
]}

Geweely, Neveen S. ^{[2
]}

Qusti, Safaa ^{[1
]}

Mohamed, M. ^{[3
]}

Kamel, A. ^{[3
]}

机构：

[1] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia

[2] Cairo Univ, Fac Sci, Dept Bot Microbiol, Giza 12613, Egypt

[3] Texas So Univ, Fac Sci, Dept Chem, Houston, TX USA

来源：

JOURNAL OF APPLIED ANIMAL RESEARCH | 2010年 / 37卷 / 01期

关键词：

Nerium oleander; cytotoxicity; antimicrobial activity; CELL-CULTURES; PLANTS; PRODUCTS; PROTEINS; CANCER; DAMAGE;

D O I：

10.1080/09712119.2010.9707089

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

El Sawi, N.M., Geweely, N.S., Qusti, S., Mohamed, M. and Kamel, A. 2010. Cytotoxicity and antimicrobial activity of Nerium oleander extracts. J. Appl. Anim. Res., 37: 25-31. The antimicrobial properties of the crude and pure extracts of Nerium oleander were investigated against three Gram -ve bacteria (Escherichia coli, Pseudomonas aeruginosa and Salmonella enteritidis), three Gram +ve bacteria (Bacillus subtilis, Listeria monocytogenes and Staphylococcus aureus) and six fungal species (Aspergillus flavus, A. fumigatus, A. niger, Fusarium moniliforme, Penicillium expansum and Rhizopus oryzae). The crude extract of N. oleander was more effective than purified compound. The maximum antimicrobial activities (15 and 20 mm inhibition zone) was exhibited by the crude extract of N. oleander against the most sensitive isolates (B. subtilis and A. Thaws), respectively, while all pure constituents showed trace to no antimicrobial activity against the tested microorganisms. The lowest value (25 mu g/ml) of minimum inhibitory concentration of the active crude extract of N. oleander was revealed with A. flavus.

引用

页码：25 / 31

页数：7

共 30 条

[11]

Goktas O, 2007, AFR J BIOTECHNOL, V6, P2000

[12]

HARTWELL JL, 1967, LLOYD, V30, P379

[13] The latent structure of attention-deficit/hyperactivity disorder: a taxometric analysis [J].

Haslam, Nick ;

Williams, Ben ;

Prior, Margot ;

Haslam, Ric ;

Graetz, Brian ;

Sawyer, Michael .

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2006, 40 (08) :639-647

[14] ANTIFUNGAL ACTIVITY OF CHITIN-BINDING PR-4 TYPE PROTEINS FROM BARLEY-GRAIN AND STRESSED LEAF [J].

HEJGAARD, J ;

JACOBSEN, S ;

BJORN, SE ;

KRAGH, KM .

FEBS LETTERS, 1992, 307 (03) :389-392

[15]

HUG M, 1999, FITOTERAPIA, V70, P5

[16] Stimulation of oleandrin production by combined Agrobacterium tumefaciens mediated transformation and fungal elicitation in Nerium oleander cell cultures [J].

Ibrahim, Amany K. ;

Khalifa, Sherief ;

Khafagi, Ishrak ;

Youssef, Diaa ;

Khan, Ikhlas ;

Mesbah, Mostafa .

ENZYME AND MICROBIAL TECHNOLOGY, 2007, 41 (03) :331-336

[17]

MADDEN TL, 2002, J EXP THERAP ONCOL, V2, P278

[18] INCREASED DISEASE SUSCEPTIBILITY OF TRANSGENIC TOBACCO PLANTS WITH SUPPRESSED LEVELS OF PREFORMED PHENYLPROPANOID PRODUCTS [J].

MAHER, EA ;

BATE, NJ ;

NI, WT ;

ELKIND, Y ;

DIXON, RA ;

LAMB, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7802-7806

[19] MICROELECTROPHORETIC STUDY OF RADIATION-INDUCED DNA DAMAGES IN INDIVIDUAL MAMMALIAN-CELLS [J].

OSTLING, O ;

JOHANSON, KJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 123 (01) :291-298

[20]

Rasheed A., 1990, PAKISTAN J BIOCH, V23, P55

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