Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle

被引：224

作者：

Stanford, Kristin I. ^{[1
]}

Goodyear, Laurie J. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sect Integrat Physiol & Metab, Joslin Diabet Ctr,Dept Med,Med Sch, Boston, MA 02215 USA

来源：

ADVANCES IN PHYSIOLOGY EDUCATION | 2014年 / 38卷 / 04期

基金：

美国国家卫生研究院;

关键词：

exercise; type; 2; diabetes; ACTIVATED PROTEIN-KINASE; INSULIN-STIMULATED PHOSPHORYLATION; LIFE-STYLE INTERVENTION; AS160; PHOSPHORYLATION; GLUT4; TRANSLOCATION; 3-KINASE ACTIVITY; AKT SUBSTRATE; CONTRACTION; TRANSPORT; AMPK;

D O I：

10.1152/advan.00080.2014

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Exercise is a well-established tool to prevent and combat type 2 diabetes. Exercise improves whole body metabolic health in people with type 2 diabetes, and adaptations to skeletal muscle are essential for this improvement. An acute bout of exercise increases skeletal muscle glucose uptake, while chronic exercise training improves mitochondrial function, increases mitochondrial biogenesis, and increases the expression of glucose transporter proteins and numerous metabolic genes. This review focuses on the molecular mechanisms that mediate the effects of exercise to increase glucose uptake in skeletal muscle.

引用

收藏

页码：308 / 314

页数：7

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