Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase

被引：36
|
作者：
Erb-Downward, John R.
Huffnagle, Gary B. [1 ]
机构：
[1] Univ Michigan, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
来源：
EUKARYOTIC CELL | 2007年 / 6卷 / 02期
关键词：
D O I：
10.1128/EC.00336-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Many single-celled eukaryotes produce prostaglandin-like molecules, but these have not been absolutely verified by mass spectrometry. We have isolated, and identified by liquid chromatography-tandem mass spectrometry, authentic prostaglandin E-2 from Cryptococcus neoformans. Cyclooxygenase inhibitors did not inhibit prostaglandin synthesis, and the cryptococcal genome lacks a cyclooxygenase homolog. Thus, novel enzymes must exist.
引用
收藏
页码：346 / 350
页数：5
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