Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase

被引：36
|
作者：
Erb-Downward, John R.
Huffnagle, Gary B. [1 ]
机构：
[1] Univ Michigan, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
来源：
EUKARYOTIC CELL | 2007年 / 6卷 / 02期
关键词：
D O I：
10.1128/EC.00336-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Many single-celled eukaryotes produce prostaglandin-like molecules, but these have not been absolutely verified by mass spectrometry. We have isolated, and identified by liquid chromatography-tandem mass spectrometry, authentic prostaglandin E-2 from Cryptococcus neoformans. Cyclooxygenase inhibitors did not inhibit prostaglandin synthesis, and the cryptococcal genome lacks a cyclooxygenase homolog. Thus, novel enzymes must exist.
引用
收藏
页码：346 / 350
页数：5
相关论文
共 50 条
  • [21] Cyclooxygenase-2 induces angiogenesis in pancreatic cancer mediated by prostaglandin E2
    Xie, Chuangao
    Xu, Xuanfu
    Wang, Xingpeng
    Wei, Shumei
    Shao, Liming
    Chen, Jiamin
    Cai, Jianting
    Jia, Litao
    ONCOLOGY LETTERS, 2018, 16 (01) : 940 - 948
  • [22] HIGH EXPRESSION OF CYCLOOXYGENASE-2, PROSTAGLANDIN E2 AND PROSTAGLANDIN E2 RECEPTOR EP4 IN ZYGAPOPHYSEAL JOINTS OF PATIENTS WITH ANKYLOSING SPONDYLITIS
    Bleil, J.
    Appel, H.
    Maier, R.
    Sieper, J.
    Syrbe, U.
    ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 : 792 - 793
  • [23] Production of prostaglandin E2 in preterm placenta: Role of cyclooxygenase inhibitors.
    Bonifacio, L
    Reddy, P
    Han, S
    Weinberger, B
    Laskin, D
    Sharma, S
    Hanna, N
    JOURNAL OF INVESTIGATIVE MEDICINE, 2003, 51 : S423 - S423
  • [24] The cardinal role of the phospholipase A2/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E2 (PCPP) axis in inflammostasis
    Mancini, A. D.
    Di Battista, J. A.
    INFLAMMATION RESEARCH, 2011, 60 (12) : 1083 - 1092
  • [25] The cardinal role of the phospholipase A2/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E2 (PCPP) axis in inflammostasis
    A. D. Mancini
    J. A. Di Battista
    Inflammation Research, 2011, 60 : 1083 - 1092
  • [26] Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2
    Benoit, V
    Relic, B
    de Leval, X
    Chariot, A
    Merville, MP
    Bours, V
    ONCOGENE, 2004, 23 (08) : 1631 - 1635
  • [27] Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2
    Valérie Benoit
    Biserka Relic
    Xavier de Leval
    Alain Chariot
    Marie-Paule Merville
    Vincent Bours
    Oncogene, 2004, 23 : 1631 - 1635
  • [28] Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skin
    Ansari, Kausar M.
    Sungy, You Me
    He, Guobin
    Fischer, Susan M.
    CARCINOGENESIS, 2007, 28 (10) : 2063 - 2068
  • [29] Meloxicam inhibits prostaglandin E2 generation via cyclooxygenase 2 in the inflammatory site but not that via cyclooxygenase 1 in the stomach
    Ogino, K
    Hatanaka, K
    Kawamura, M
    Ohno, T
    Harada, Y
    PHARMACOLOGY, 2000, 61 (04) : 244 - 250
  • [30] Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2
    Kino, Y
    Kojima, F
    Kiguchi, K
    Igarashi, R
    Ishizuka, B
    Kawai, S
    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2005, 73 (02): : 103 - 111
12345