Different spectrophotometric methods applied for the analysis of binary mixture of flucloxacillin and amoxicillin: A comparative study

被引：28
作者：
Attia, Khalid A. M. [1 ]
Nassar, Mohammed W. I. [1 ]
El-Zeiny, Mohamed B. [2 ]
Serag, Ahmed [1 ]
机构：
[1] Al Azhar Univ, Dept Pharmaceut Analyt Chem, Fac Pharm, Cairo 11751, Egypt
[2] Modern Univ Technol & Informat MTI, Fac Pharm, Dept Analyt Chem, Cairo 12582, Egypt
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2016年 / 161卷
关键词：
Flucloxacillin; Amoxicillin; Ratio subtraction; Absorbance subtraction; Amplitude modulation; LIQUID-CHROMATOGRAPHIC ANALYSIS; BETA-LACTAM ANTIBIOTICS; CARBON-PASTE ELECTRODE; DOSAGE FORMS; PHARMACEUTICAL FORMULATIONS; VOLTAMMETRIC DETERMINATION; HPLC METHOD; AMPICILLIN; PURE; PLASMA;
D O I：
10.1016/j.saa.2016.02.028
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Three different spectrophotometric methods were applied for the quantitative analysis of flucloxacillin and amoxicillin in their binary mixture, namely, ratio subtraction, absorbance subtraction and amplitude modulation. A comparative study was done listing the advantages and the disadvantages of each method. All the methods were validated according to the ICH guidelines and the obtained accuracy, precision and repeatability were found to be within the acceptable limits. The selectivity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. So, they can be used for the routine analysis of flucloxacillin and amoxicillin in their binary mixtures. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：64 / 69
页数：6
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