Anti-Mullerian hormone in grazing dairy cows: Identification of factors affecting plasma concentration, relationship with phenotypic fertility, and genome-wide associations

被引:22
作者
Gobikrushanth, M. [1 ,2 ]
Purfield, D. C. [2 ]
Canadas, E. R. [2 ]
Herlihy, M. M. [2 ]
Kenneally, J. [2 ]
Murray, M. [3 ]
Kearney, F. J. [4 ]
Colazo, M. G. [5 ]
Ambrose, D. J. [1 ,5 ]
Butler, S. T. [2 ]
机构
[1] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada
[2] TEAGASC, Anim & Grassland Res & Innovat Ctr, Moorepk, Fermoy P61 C996, Cork, Ireland
[3] TEAGASC, Dunsany C15 PW93, Meath, Ireland
[4] Irish Cattle Breeding Assoc, Highfield House, Bandon P72 X050, Cork, Ireland
[5] Alberta Agr & Forestry, Livestock Syst Sect, Edmonton, AB T6H 5T6, Canada
关键词
ovarian reserve; reproductive phenotype; antral follicle count; genome-wide association study; ANTRAL FOLLICLE COUNT; SUPEROVULATORY RESPONSE; OVARIAN; IMPACT; AMH; HERITABILITY; POPULATION; EXPRESSION; UTILITY; MARKER;
D O I
10.3168/jds.2019-16979
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
The objectives of this study were to (1) characterize the distribution and variability of plasma anti-Mullerian hormone (AMH) concentration; (2) evaluate factors associated with phenotypic variation in plasma AMH; (3) examine the associations between categories of plasma AMH and reproductive outcomes [pregnancy to first artificial insemination (P/AI), and pregnancy rates within 21, 42, and 84 d after the mating start date (MSD)]; (4) estimate pedigree and genomic heritability for plasma AMH; and (5) identify and validate SNP associated with phenotypic variation in plasma AMH. Plasma AMII concentration (pg/mL) was determined from a blood sample collected (mean +/- standard deviation) 10 +/- 2 d after first insemination at detected estrus (IDE) in 2,628 first- and second-parity Irish dairy cows. Overall, plasma AMII had a positively skewed distribution with mean (+/- standard deviation), median, minimum, and maximum concentrations of 326 +/- 231, 268, 15, and 2,863 pg/mL, respectively. Plasma AMH was greatest for Jersey, followed by Holstein x Jersey, Holstein x Norwegian Red, and Holstein cows (410, 332, 284, and 257 pg/mL, respectively). Second-parity cows had greater plasma AMH than first-parity cows (333 vs. 301 pg/mL, respectively). Samples collected at 7 and 8 d after first IDE had lesser plasma AMH than those collected on d 9, 10, 11, 12, and 13 after first IDE (291 and 297 vs. 317, 319, 331, 337, and 320 pg/mL). Plasma AMII was not associated with either body condition score at first IDE or the interval from calving to MSD. Cows were categorized into low (<= 150 pg/mL; n = 526; lowest 20%), intermediate (>150 to <= 461 pg/mL; n = 1,576; intermediate 60%), and high AMH (>461 pg/mL; n = 526; highest 20%) groups based on plasma AMH, and associations with reproductive outcomes were tested. Cows with high and intermediate plasma AMH had 1.42- and 1.51-times-greater odds of becoming pregnant within 84 d after the MSD than those with low plasma AMH (90.3 and 90.8 vs. 86.8%, respectively); however, P/AI and pregnancy rate within 21 and 42 d after the MSD did not differ among AMH categories. Plasma AMH was moderately heritable (pedigree heritability of 0.40 +/- 0.06 and genomic heritability of 0.45 .1.: 0.05), and 68 SNP across Bos taurus autosomes 7 and 11 were associated with phenotypic variation in plasma AMH. Out of 68 SNP, 42 were located in a single quantitative trait locus on Bos taurus autosome 11 that harbored 6 previously identified candidate genes (NR5A1, HSPA5, CRB2, DENND1A, NDUFA8, and PTGS) linked to fertility-related phenotypes in dairy cows.
引用
收藏
页码:11622 / 11635
页数:14
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