Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts

被引：55

作者：

Cai, Yutong ^{[1
]}

Schikowski, Tamara ^{[2
,3
,4
]}

Adam, Martin ^{[2
,3
]}

Buschka, Anna ^{[4
]}

Carsin, Anne-Elie ^{[5
]}

Jacquemin, Benedicte ^{[5
,6
,7
]}

Marcon, Alessandro ^{[8
]}

Sanchez, Margaux ^{[6
,7
]}

Vierkoetter, Andrea ^{[4
]}

Al-Kanaani, Zaina ^{[1
]}

Beelen, Rob ^{[9
]}

Birk, Matthias ^{[10
,11
]}

Brunekreef, Bert ^{[9
]}

Cirach, Marta ^{[5
]}

Clavel-Chapelon, Franoise ^{[7
,12
]}

Declercq, Christophe ^{[13
]}

de Hoogh, Kees ^{[1
,2
,3
]}

de Nazelle, Audrey ^{[5
,14
]}

Ducret-Stich, Regina E. ^{[2
,3
]}

Ferretti, Virginia Valeria ^{[15
]}

Forsberg, Bertil ^{[16
]}

Gerbase, Margaret W. ^{[17
]}

Hardy, Rebecca ^{[18
]}

Heinrich, Joachim ^{[10
,11
]}

Hoek, Gerard ^{[9
]}

Jarvis, Debbie ^{[1
,19
]}

Keidel, Dirk ^{[2
,3
]}

Kuh, Diana ^{[18
]}

Nieuwenhuijsen, Mark J. ^{[5
]}

Ragettli, Martina S. ^{[2
,3
]}

Ranzi, Andrea ^{[20
]}

Rochat, Thierry ^{[17
]}

Schindler, Christian ^{[2
,3
]}

Sugiri, Dorothea ^{[4
]}

Temam, Sofia ^{[6
,7
]}

Tsai, Ming-Yi ^{[2
,3
]}

Varraso, Raphaelle ^{[6
,7
]}

Kauffmann, Francine ^{[6
,7
]}

Kraemer, Ursula ^{[4
]}

Sunyer, Jordi ^{[5
]}

Kuenzli, Nino ^{[2
,3
]}

Probst-Hensch, Nicole ^{[2
,3
]}

Hansell, Anna L. ^{[1
,21
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London W2 1PG, England

[2] Swiss Trop & Publ Hlth Inst, Basel, Switzerland

[3] Univ Basel, Basel, Switzerland

[4] Leibniz Res Inst Environm Med IUF, Dusseldorf, Germany

[5] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[6] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, U1018, Resp & Environm Epidemiol Team, Villejuif, France

[7] Univ Paris 11, UMRS 1018, F-94807 Villejuif, France

[8] Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37100 Verona, Italy

[9] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[10] German Res Ctr Environm Hlth, Inst Epidemiol 1, Neuherberg, Germany

[11] German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany

[12] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, U1018, Nutr Hormones & Womens Hlth Team, Villejuif, France

[13] French Inst Publ Hlth Surveillance, St Maurice, France

[14] Univ London Imperial Coll Sci Technol & Med, Ctr Environm Policy, London W2 1PG, England

[15] Univ Pavia, Dept Publ Hlth Neurosci Expt & Forens Med, Sect Biostat & Clin Epidemiol, I-27100 Pavia, Italy

[16] Umea Univ, Dept Publ Hlth & Clin Med Occupat & Environm Med, Umea, Sweden

[17] Univ Hosp Geneva, Div Pulm Med, Geneva, Switzerland

[18] UCL, Inst Epidemiol & Hlth Care, MRC Unit Lifelong Hlth & Ageing, London, England

[19] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London W2 1PG, England

[20] Reg Agcy Environm Prevent Emilia Romagna, Environm Hlth Reference Ctr, Modena, Italy

[21] Imperial Coll Healthcare NHS Trust, Directorate Publ Hlth & Primary Care, London, England

来源：

THORAX | 2014年 / 69卷 / 11期

基金：

瑞士国家科学基金会; 英国医学研究理事会;

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; TERM AMBIENT CONCENTRATIONS; USE REGRESSION-MODELS; RESPIRATORY SYMPTOMS; PARTICULATE MATTER; AUTOMOBILE EXHAUST; EXPOSURE; ADULTS; PARTICLES; HEALTH;

D O I：

10.1136/thoraxjnl-2013-204352

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in five cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE) project. Methods Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE measurement campaigns 2008-2011 were assigned to home address at most recent assessments (1998-2011). Symptoms examined were chronic bronchitis (cough and phlegm for >= 3 months of the year for >= 2 years), chronic cough (with/without phlegm) and chronic phlegm (with/without cough). Cohort-specific cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis. Results 15 279 and 10 537 participants respectively were included in the main NO2 and PM analyses at assessments in 1998-2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO2 and PM10 for assessments in 1985-2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic phlegm with PMcoarse OR 1.31 (1.05 to 1.64) per 5 mu g/m(3) increase and PM10 with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs (black carbon) exposures. Conclusions Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations.

引用

页码：1005 / 1014

页数：10

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