Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis:: Producing strain, isolation and biological activity

被引：51

作者：

Tanaka, Y

Komaki, H

Yazawa, K

Mikami, Y

Nemoto, A

Tojyo, T

Kadowaki, K

Shigemori, H

Kobayashi, J

机构：

[1] Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chuo Ku, Chiba 260, Japan

[2] Higeta Shoyu Co Ltd, Res Lab, Chiba 288, Japan

[3] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 060, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 12期

关键词：

D O I：

10.7164/antibiotics.50.1036

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was only active against Aspergillus niger, but not active against other fungi including yeasts as well as other filamentous like fungi and bacteria. Brasilinolide A exerted an immunosuppressive activity in the assay system of a mixed lymphocyte reaction (MLR).

引用

页码：1036 / 1041

页数：6

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