Prognostic factors in patients with advanced cancer and COVID-19: a cohort from the Palliative Care Unit of the Brazilian National Cancer Institute

被引：6
作者：
de Oliveira, Livia Costa [1 ]
da Costa Rosa, Karla Santos [1 ]
Borsatto, Alessandra Zanei [1 ]
de Oliveira, Luciana Aparecida Faria [1 ]
de Freitas, Renata [1 ]
dos Santos Machado Sampaio, Simone Garruth [1 ]
机构：
[1] Natl Canc Inst Jose Alencar Gomes Silva INCA, Palliat Care Unit, Rua Visconde Santa Isabel 274, BR-20560120 Rio De Janeiro, RJ, Brazil
来源：
SUPPORTIVE CARE IN CANCER | 2021年 / 29卷 / 10期
关键词：
Coronavirus; Palliative care; Hospital mortality; Advanced cancer; Prognosis;
D O I：
10.1007/s00520-021-06149-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective To describe overall survival (OS) in 90 days and to evaluate the prognostic factors in patients with advanced cancer and COVID-19. Methods This is a retrospective cohort study carried out at the Palliative Care Unit of the Brazilian National Cancer Institute. Patients with advanced cancer and COVID-19 confirmed by Reverse Transcription Polymerase Chain Reaction were included. Kaplan-Meier's curves, log-rank test, and Cox regression were performed. Results Eighty-three inpatients were selected. The average age was 61.4 (+/- 12.6) years, with a higher proportion of women (73.4%). The most prevalent tumor type was breast (36.7%), followed by gastrointestinal tract (20.3%). The OS was 32 [interquartile range (IQR): 6-70] days, and at the end of the follow-up period, 17 patients (20.5%) were alive and 66 (79.5%) had died. Patients with advanced cancer and COVID-19 and who were 60-74 years old [hazard ratio (HR): 2.03; 95% confidence interval (CI): 1.09-3.78], with lung tumors (HR: 17.50; 95% CI: 1.70-28.34), with lung metastasis (HR: 4.21; 95% CI: 2.17-8.15), and with chronic obstructive pulmonary disease (HR: 4.92; 95% CI: 1.01-24.69) had higher risk of death in 90 days. Conclusion The age of 60-74 years old, lung tumors (primary or metastases), and the presence of chronic obstructive pulmonary disease were considered independent prognostic factors in patients with advanced cancer and COVID-19.
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页码：6005 / 6012
页数：8
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