Copper carbenoid mediated N-alkylation of imidazoles and its use in a novel synthesis of bifonazole

被引：37
作者：
Cuevas-Yañez, E
Serrano, JM
Huerta, G
Muchowski, JM
Cruz-Almanza, R
机构：
[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
[2] Roche Palo Alto, Chem, Palo Alto, CA 94304 USA
来源：
TETRAHEDRON | 2004年 / 60卷 / 42期
关键词：
copper; carbenoid; imidazole; bifonazole;
D O I：
10.1016/j.tet.2004.08.009
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1H-Imidazoles are readily N-alkylated by a Cu(acac)(2) mediated reaction with alpha-diazocarbonyl compounds or with diazoalkanes generated in situ from the corresponding p-toluensulfonyl hydrazones. The antifungal agent bifonazole was prepared by the latter method. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9391 / 9396
页数：6
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