Synthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety

被引：18
作者：
Yu, Wei [1 ]
Zhai, Zhi-Wen [1 ]
Wedge, David E. [2 ]
Duke, Stephen O. [2 ]
Wu, Hong-Ke [1 ]
Weng, Jian-Quan [1 ]
Tan, Cheng-Xia [1 ]
Zhang, Yong-Gang [3 ]
Liu, Xing-Hai [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China
[2] USDA ARS, Nat Prod Utilizat Res Unit, University, MS 38677 USA
[3] Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Jinan, Shandong, Peoples R China
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2019年 / 45卷 / 12期
关键词：
Oxadiazole; Pyrazole; Synthesis; Fungicide; Herbicide; CRYSTAL-STRUCTURE; NEMATOCIDAL ACTIVITY; ANTIFUNGAL ACTIVITY; FUNGICIDAL ACTIVITY; 1,2,3-THIADIAZOLE DERIVATIVES; ANTIMICROBIAL ACTIVITY; HERBICIDAL ACTIVITY; EFFICIENT SYNTHESIS; ONE-POT; HYDRAZONE;
D O I：
10.1007/s11164-019-04015-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring were designed and synthesized from ethyl acetoacetate and triethyl orthoformate as starting materials via multi-step reactions. The compound structures were confirmed by melting point, H-1 NMR and HRMS. They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate-to-good activity as a herbicide.
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收藏
页码：5989 / 6001
页数：13
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