Site-isolated base- and acid-mediated Michael-initiated cyclization cascades

被引：62
作者：
Pilling, Adam W.
Boehmer, Jutta
Dixon, Darren J.
机构：
[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England
[2] Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 28期
关键词：
cascade reactions; cyclization; iminium ions; Michael addition; N-ACYLIMINIUM IONS; ONE-POT REACTIONS; OPPOSING REAGENTS; ORGANIC CATALYSTS; ENZYME;
D O I：
10.1002/anie.200701079
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) One thing leads to another: Site-isolated base and acid catalysts have been exploited in Michael addition, N-acyl iminium ion cyclization cascades with amide pronucleophiles and α,β- unsaturated carbonyl compounds. The reaction sequence has broad scope, uses commercially available catalysts, is atom efficient, and can be scaled by way of a flow-reactor setup. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5428 / 5430
页数：3
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