Dysregulation of cellular signaling in gastric cancer

被引：181

作者：

Wu, William K. K. ^{[1
,2
]}

Cho, Chi H. ^{[1
,2
,3
]}

Lee, Chung W. ^{[1
,2
]}

Fan, Daiming ^{[4
,5
]}

Wu, Kaichun ^{[4
,5
]}

Yu, Jun ^{[1
,2
]}

Sung, Joseph J. Y. ^{[1
,2
]}

机构：

[1] Chinese Univ Hong Kong, Inst Digest Dis, LKS Inst Hlth, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Hong Kong, Hong Kong, Peoples R China

[4] Fourth Mil Med Univ, Xijing Hosp, State Key Lab Canc Biol, Xian 710032, Peoples R China

[5] Fourth Mil Med Univ, Xijing Hosp, Inst Digest Dis, Xian 710032, Peoples R China

来源：

CANCER LETTERS | 2010年 / 295卷 / 02期

关键词：

Cell signaling; Gastric cancer; Nuclear factor kappa B; Wnt; Notch; FACTOR-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; HELICOBACTER-PYLORI INFECTION; SONIC HEDGEHOG EXPRESSION; E-CADHERIN; EPITHELIAL-CELLS; BETA-CATENIN; TGF-BETA; CYCLIN-E; TRANSCRIPTION FACTOR;

D O I：

10.1016/j.canlet.2010.04.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The pathogenesis of gastric cancer is complex and related to multiple factors. Dysregulation of intracellular signaling pathways represents a common pathogenic mechanism and may be amenable to drug targeting. Multiple well-established oncogenic pathways, such as those mediated by cell cycle regulators, nuclear factor-kappa B, cyclooxygenase-2 and epidermal growth factor receptor are implicated in gastric carcinogenesis. Emerging evidence also underscores the importance of signaling pathways involved in the developmental process, including transforming growth factor-beta/bone morphogenetic protein signaling, Wnt/beta-catenin signaling, Hedgehog signaling and Notch signaling. Understanding their biological significance will provide a rational basis for drug development. Their relative importance and cross-talk in gastric carcinogenesis, however, are still not completely understood and warrant further investigation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：144 / 153

页数：10

共 133 条

[1] p21 in cancer: intricate networks and multiple activities [J].