Antibacterial and In vivo Cytotoxic Activities of the Leaves of Leucas aspera

被引:3
|
作者
Alam, Mohammad Sayed [1 ,2 ]
Saha, Sanjit [2 ]
Lee, Dong-Ung [1 ]
机构
[1] Dongguk Univ, Div Biosci, Gyeongju 780714, South Korea
[2] Jagannath Univ, Dept Chem, Dhaka 1100, Bangladesh
来源
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2014年 / 57卷 / 05期
关键词
antibacterial activity; cytotoxicity; Leucas aspera; Labiatae; ANTIMICROBIAL ACTIVITY; MEDICINAL-PLANT; ANTIOXIDANT; IDENTIFICATION; CONSTITUENTS;
D O I
10.1007/s13765-014-4202-1
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Antimicrobial and cytotoxic activities of the leaves of Leucas aspera, a medicinal plant found in Bangladesh, were evaluated. In vitro bactericidal activity was screened against ten pathogenic or food poisoning bacteria using the disc diffusion method. In vivo cytotoxicity was examined against Anemia sauna (brine shrimp nauplii). The dichloromethane fraction of the methanol extract of the leaves of Leucas aspera had strong antibacterial and cytotoxic effects, whereas the ethyl acetate fraction exhibited significant bactericidal activity against only Gram-positive bacterial strains. The active constituents, a-amyrin and a-tocopherol, were isolated for the first time from the dichloromethane fraction and their cytotoxic effects against A. sauna were significant with LC50 values of 241 and 195 ppm, respectively.
引用
收藏
页码:551 / 554
页数:4
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