HPLC-SPE-NMR characterization of sesquiterpenes in an antimycobacterial fraction from Warburgia salutaris

被引：23
作者：
Clarkson, Cailean
Madikane, Eliya V.
Hansen, Steen Honore
Smith, Peter J.
Jaroszewski, Jerzy W.
机构：
[1] Univ Copenhagen, Fac Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark
[2] Univ Cape Town, Dept Med, ZA-7925 Cape Town, South Africa
[3] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
[4] Univ Copenhagen, Fac Pharmaceut Sci, Dept Pharmaceut & Anal Chem, Copenhagen, Denmark
来源：
PLANTA MEDICA | 2007年 / 73卷 / 06期
关键词：
Warburgia salutaris; Canellaceae; HPLC-SPE-NMR; sesquiterpenoids; drimanes; coloratanes; mycobacteria;
D O I：
10.1055/s-2007-967187
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
HPLC-SPE-NMR analysis of a chemically complex antimycobacterial fraction of Warburgia salutaris allowed the rapid identification of seven new and four known drimane- and coloratanetype sesquiterpenes. This recently introduced hyphenated technique is therefore a highly valuable tool for elucidation of the chemistry of biologically active fractions of natural origin.
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收藏
页码：578 / 584
页数：7
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