Dietary glycemic index is inversely associated with the risk of Parkinson's disease: A case-control study in Japan

被引：45

作者：

Murakami, Kentaro ^{[2
]}

Miyake, Yoshihiro ^{[1
]}

Sasaki, Satoshi ^{[2
]}

Tanaka, Keiko ^{[1
]}

Fukushima, Wakaba ^{[3
]}

Kiyohara, Chikako ^{[4
]}

Tsuboi, Yoshio ^{[5
]}

Yamada, Tatsuo ^{[5
]}

Oeda, Tomoko ^{[6
,7
]}

Miki, Takami ^{[8
]}

Kawamura, Nobutoshi ^{[9
]}

Sakae, Nobutaka ^{[9
]}

Fukuyama, Hidenao ^{[10
]}

Hirota, Yoshio ^{[3
]}

Nagai, Masaki ^{[11
]}

机构：

[1] Fukuoka Univ, Fac Med, Dept Publ Hlth, Fukuoka 81401, Japan

[2] Univ Tokyo, Sch Publ Hlth, Dept Social & Prevent Epidemiol, Tokyo, Japan

[3] Osaka City Univ, Grad Sch Med, Dept Publ Hlth, Osaka 558, Japan

[4] Kyushu Univ, Grad Sch Med Sci, Dept Prevent Med, Fukuoka 812, Japan

[5] Fukuoka Univ, Fac Med, Dept Neurol, Fukuoka 81401, Japan

[6] Natl Utano Hosp, Clin Res Inst, Kyoto, Japan

[7] Natl Utano Hosp, Dept Neurol, Kyoto, Japan

[8] Osaka City Univ, Grad Sch Med, Dept Geriatr & Neurol, Osaka 558, Japan

[9] Kyushu Univ, Grad Sch Med Sci, Dept Neurol, Fukuoka 812, Japan

[10] Kyoto Univ, Grad Sch Med, Human Brain Res Ctr, Kyoto, Japan

[11] Saitama Med Univ, Fac Med, Dept Publ Hlth, Saitama, Japan

来源：

NUTRITION | 2010年 / 26卷 / 05期

关键词：

Glycemic index; Glycemic load; Parkinson's disease; Japan; Case-control study; HISTORY QUESTIONNAIRE; MIXED MEALS; LOAD VALUES; INSULIN; VALIDITY; GLUCOSE; SINGLE; WOMEN;

D O I：

10.1016/j.nut.2009.05.021

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objective: High glycemic index (GI) or glycemic load (GL) carbohydrates might be expected to decrease the risk of Parkinson's disease (PD) by an insulin-induced increase in brain dopamine We conducted a hospital-based case-control study in Japan to examine associations between dietary GI and GL and other dietary carbohydrate variables, including intake of available carbohydrate and dietary fiber, and PD Methods: Patients with PD diagnosed using the U K Parkinson's Disease Society Brain Bank criteria (n = 249) and controls without neurodegenerative diseases (n = 368) were recruited Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered. semiquantitative, comprehensive diet history questionnaire. Results: After adjustment for potential dietary and non-dietary confounding factors. dietary Cl was significantly Inversely associated with the risk of PD. Multivariate odds ratios (95% confidence intervals) for PD in the first. second. third, and fourth quartiles of dietary GI were 1.00 (reference). 1.03 (0 64-1 66). 0 68 (0 4 1-1.15), and 0 61 (0 34-1.09). respectively (P for trend = 0 04) Conversely. 110 significant association was observed for other dietary carbohydrates, including dietary GL (P for trend = 0 77). available carbohydrate intake (P for trend = 0 28), or dietary fiber intake (P for trend = 0 73). Conclusion: This preliminary case-control study based on current dietary habits found an independent inverse relation between dietary GI and PD Considering the plausibility of the putative mechanism. further investigation using a case-control design with accurate assessment of past dietary habits or a prospective design is warranted. (C) 2010 Elsevier Inc All rights reserved

引用

页码：515 / 521

页数：7

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