A catalytic amount of nickel(II) chloride hexahydrate and 1,2-ethanedithiol is a good combination for the cleavage of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers

被引：32
作者：
Khan, AT [1 ]
Islam, S
Choudhury, LH
Ghosh, S
机构：
[1] Indian Inst Technol, Dept Chem, Gauhati 781039, India
[2] Visva Bharati Univ, Dept Chem, Santini Ketan 731235, W Bengal, India
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 52期
关键词：
deprotection of TBS and THP ethers;
D O I：
10.1016/j.tetlet.2004.11.011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various THP and TBS ethers can be unmasked easily to the corresponding hydroxyl compounds in good yields by using a combination of a catalytic amount of nickel(II) chloride hexahydrate and 1,2-ethanedithiol at room temperature. In addition, alkyl TBS ethers can be hydrolyzed chemo selectively in the presence of aryl TBS ethers. Moreover, alkyl TBS ethers can be cleaved easily in the presence of alkyl or aryl THP ethers using the same conditions. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码：9617 / 9621
页数：5
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