Polymorphisms of the γ-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico

被引：21

作者：

Organista-Nava, Jorge ^{[1
]}

Gomez-Gomez, Yazmin ^{[1
]}

Virginia Saavedra-Herrera, Monica ^{[1
]}

Rivera-Ramirez, Bertha ^{[2
]}

Antonio Teran-Porcayo, Marco ^{[2
]}

del Carmen Alarcon-Romero, Luz ^{[3
]}

Illades-Aguiar, Berenice ^{[1
]}

Antonio Leyva-Vazquez, Marco ^{[1
]}

机构：

[1] Univ Autonoma Guerrero, Unidad Acad Ciencias Quim Biol, Lab Biomed Mol, Chilpancingo 39090, Guerrero, Mexico

[2] Inst Estatal Cancerol Arturo Beltron Ortega, Acapulco, Guerrero, Mexico

[3] Univ Autonoma Guerrero, Unidad Acad Ciencias Quim Biol, Lab Citopatol, Chilpancingo 39090, Guerrero, Mexico

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 06期

关键词：

Acute lymphoblastic leukemia; gamma-Glutamyl hydrolase; Risk of relapse; Single nucleotide polymorphism; -401C/T polymorphism; +452C/T polymorphism; SINGLE-NUCLEOTIDE POLYMORPHISMS; REDUCED FOLATE CARRIER; RHEUMATOID-ARTHRITIS; COMMON POLYMORPHISMS; METHOTREXATE; PATHWAY; EXPRESSION; PROMOTER; TISSUES; RNA;

D O I：

10.1016/j.leukres.2009.11.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study evaluated the association of -401C/T and +452C/T polymorphisms of gamma-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the -401C/T polymorphism and the risk of relapse was found (p = 0.028), patients with the -401T/T genotype have 10.83 (95% CI 1.30-90.14) more chance of a relapse of leukemia. No association was found between the +452C/T polymorphism and the risk of relapse. Therefore, our investigation suggests that the -401C/T polymorphism in the gamma-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with ALL. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：728 / 732

页数：5

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