Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection

被引:7
|
作者
Graf, Christiana [1 ]
Mondorf, Antonia [1 ]
Knop, Viola [1 ]
Peiffer, Kai-Henrik [1 ]
Dietz, Julia [1 ]
Friess, Julia [1 ]
Wedemeyer, Heiner [2 ,3 ]
Buggisch, Peter [4 ]
Mauss, Stefan [5 ]
Berg, Thomas [6 ]
Rausch, Michael [7 ]
Sprinzl, Martin [8 ]
Klinker, Hartwig [9 ]
Hinrichsen, Holger [10 ]
Bronowicki, Jean-Pierre [11 ]
Haag, Sebastian [12 ]
Hueppe, Dietrich [13 ]
Lutz, Thomas [14 ]
Poynard, Thierry [15 ]
Zeuzem, Stefan [1 ]
Friedrich-Rust, Mireen [1 ]
Sarrazin, Christoph [1 ,16 ]
Vermehren, Johannes [1 ]
机构
[1] Univ Hosp Frankfurt, Dept Internal Med 1, Frankfurt, Germany
[2] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany
[3] Univ Hosp Essen, Dept Gastroenterol & Hepatol, D-45147 Essen, Germany
[4] Inst Interdisciplinary Med IFI, D-20099 Hamburg, Germany
[5] Ctr HIV & Hepatogastroenterol, D-40237 Dusseldorf, Germany
[6] Univ Hosp Leipzig, Dept Gastroenterol & Rheumatol, D-04103 Leipzig, Germany
[7] Internal Med, D-10777 Berlin, Germany
[8] Johannes Gutenberg Univ Mainz, Dept Internal Med 1, Univ Med Ctr, D-55131 Mainz, Germany
[9] Univ Hosp Wurzburg, Dept Med 2, Div Hepatol, D-97080 Wurzburg, Germany
[10] Gastroenterol Hepatol Ctr, D-24105 Kiel, Germany
[11] Hop Brabois CHU Nancy, Hepatogastroenterol, F-54500 Vandoeuvre Les Nancy, France
[12] Gastroenterol, D-65189 Wiesbaden, Germany
[13] Hepatol, D-44623 Herne, Germany
[14] Infektiologikum, D-60596 Frankfurt, Germany
[15] BioPredictive, F-75007 Paris, France
[16] St Josefs Hosp, Dept Gastroenterol, D-65189 Wiesbaden, Germany
关键词
HBV; non-invasive fibrosis assessment; point shear wave elastography; acoustic radiation force impulse imaging; transient elastography; fibrotest; APRI; FIB-4; LIVER STIFFNESS MEASUREMENT; CHRONIC HEPATITIS-B; SIMPLE NONINVASIVE INDEX; TRANSIENT ELASTOGRAPHY; VIRUS-INFECTION; OUTCOMES; PREDICT; HBSAG;
D O I
10.3390/jcm8122101
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.
引用
收藏
页数:11
相关论文
共 50 条
  • [41] Acoustic radiation force impulse point shear wave elastography of the liver and spleen in patients with Gaucher disease type 1: Correlations with clinical data and markers of disease severity
    Lollert, Andre
    Hoffmann, Christian
    Lache, Michael
    Koenig, Jochem
    Brixius-Huth, Miriam
    Hennermann, Julia B.
    Dueber, Christoph
    Staatz, Gundula
    MOLECULAR GENETICS AND METABOLISM, 2020, 130 (02) : 140 - 148
  • [42] Liver and Spleen Stiffness Measured by Acoustic Radiation Force Impulse Elastography for Noninvasive Assessment of Liver Fibrosis and Esophageal Varices in Patients With Chronic Hepatitis B
    Ye, Xiao-Ping
    Ran, Hai-Tao
    Cheng, Juan
    Zhu, Ye-Feng
    Zhang, Da-Zhi
    Zhang, Ping
    Zheng, Yuan-Yi
    JOURNAL OF ULTRASOUND IN MEDICINE, 2012, 31 (08) : 1245 - 1253
  • [43] Assessment of liver fibrosis with acoustic radiation force impulse imaging versus liver histology in patients with chronic hepatitis C: a pilot study
    Kohla, Mohamed A. S.
    Abbasy, Mohamed
    Abozeid, Mai
    El-Abd, Osama
    Ezzat, Sameera
    Kohla, Samah
    Abdel-Rahman, Mohamed
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2017, 29 (08) : 951 - 955
  • [44] Determination and prospective validation of cut-off values for the diagnosis of liver cirrhosis for point shear-wave elastography/acoustic radiation force impulse imaging using the ACUSON Sequoia ultrasound system
    Meitner-Schellhaas, B.
    Schueler, S.
    Vogl, T.
    Jesper, D.
    Vetter, M.
    Waldner, M.
    Strobel, D.
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2024, 36 (01) : 135 - 140
  • [45] Prospective Assessment of Correlation between US Acoustic Radiation Force Impulse and MR Elastography in a Pediatric Population: Dispersion of US Shear-Wave Speed Measurement Matters
    Trout, Andrew T.
    Dillman, Jonathan R.
    Xanthakos, Stavra
    Kohli, Rohit
    Sprague, Garrett
    Serai, Suraj
    Mahley, Alana D.
    Podberesky, Daniel J.
    RADIOLOGY, 2016, 281 (02) : 544 - 552
  • [46] Noninvasive assessment of hepatic sinusoidal obstructive syndrome using acoustic radiation force impulse elastography imaging: A proof-of-concept study in rat models
    Park, So Hyun
    Lee, Seung Soo
    Sung, Ji-Youn
    Na, Kiyong
    Kim, Hyoung Jung
    Kim, So Yeon
    Park, Beom Jin
    Byun, Jae Ho
    EUROPEAN RADIOLOGY, 2018, 28 (05) : 2096 - 2106
  • [47] Point ShearWave Elastography by Acoustic Radiation Force Impulse Quantification in Comparison to Transient Elastography for the Noninvasive Assessment of Liver Fibrosis in Chronic Hepatitis C: A Prospective International Multicenter Study
    Friedrich-Rust, M.
    Lupsor, M.
    de Knegt, R.
    Dries, V.
    Buggisch, P.
    Gebel, M.
    Maier, B.
    Herrmann, E.
    Sagir, A.
    Zachoval, R.
    Shi, Y.
    Schneider, M. D.
    Badea, R.
    Rifai, K.
    Poynard, T.
    Zeuzem, S.
    Sarrazin, C.
    ULTRASCHALL IN DER MEDIZIN, 2015, 36 (03): : 239 - 247
  • [48] NORMAL VALUES OF LIVER SHEAR WAVE VELOCITY IN HEALTHY CHILDREN ASSESSED BY ACOUSTIC RADIATION FORCE IMPULSE IMAGING USING A CONVEX PROBE AND A LINEAR PROBE
    Fontanilla, Teresa
    Canas, Teresa
    Macia, Araceli
    Alfageme, Marta
    Gutierrez Junquera, Carolina
    Malalana, Ana
    Luz Cilleruelo, Maria
    Roman, Enriqueta
    Miralles, Maria
    ULTRASOUND IN MEDICINE AND BIOLOGY, 2014, 40 (03) : 470 - 477
  • [49] ACOUSTIC RADIATION FORCE IMPULSE (ARFI) IMAGING VERSUS TISSUE ELASTOGRAPHY AND SEROLOGICAL MARKERS FOR ASSESSMENT OF LIVER GRAFT FIBROSIS PRE AND POST ANTIVIRAL THERAPY FOR HEPATITIS C VIRUS RECURRENC
    Anwar, Ismail
    El Serafy, Magdy
    Said, Mohamed
    Elbaz, Tamer
    Magdy, Mahmoud
    Eletreby, Rasha
    Yosry, Ayman
    TRANSPLANT INTERNATIONAL, 2017, 30 : 492 - 492
  • [50] Acoustic radiation force impulse elastography, FibroScan®, Forns' index and their combination in the assessment of liver fibrosis in patients with chronic hepatitis B, and the impact of inflammatory activity and steatosis on these diagnostic methods
    Dong, Dao-Ran
    Hao, Mei-Na
    Li, Cheng
    Peng, Ze
    Liu, Xia
    Wang, Gui-Ping
    Ma, An-Lin
    MOLECULAR MEDICINE REPORTS, 2015, 11 (06) : 4174 - 4182