Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection

被引:7
|
作者
Graf, Christiana [1 ]
Mondorf, Antonia [1 ]
Knop, Viola [1 ]
Peiffer, Kai-Henrik [1 ]
Dietz, Julia [1 ]
Friess, Julia [1 ]
Wedemeyer, Heiner [2 ,3 ]
Buggisch, Peter [4 ]
Mauss, Stefan [5 ]
Berg, Thomas [6 ]
Rausch, Michael [7 ]
Sprinzl, Martin [8 ]
Klinker, Hartwig [9 ]
Hinrichsen, Holger [10 ]
Bronowicki, Jean-Pierre [11 ]
Haag, Sebastian [12 ]
Hueppe, Dietrich [13 ]
Lutz, Thomas [14 ]
Poynard, Thierry [15 ]
Zeuzem, Stefan [1 ]
Friedrich-Rust, Mireen [1 ]
Sarrazin, Christoph [1 ,16 ]
Vermehren, Johannes [1 ]
机构
[1] Univ Hosp Frankfurt, Dept Internal Med 1, Frankfurt, Germany
[2] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany
[3] Univ Hosp Essen, Dept Gastroenterol & Hepatol, D-45147 Essen, Germany
[4] Inst Interdisciplinary Med IFI, D-20099 Hamburg, Germany
[5] Ctr HIV & Hepatogastroenterol, D-40237 Dusseldorf, Germany
[6] Univ Hosp Leipzig, Dept Gastroenterol & Rheumatol, D-04103 Leipzig, Germany
[7] Internal Med, D-10777 Berlin, Germany
[8] Johannes Gutenberg Univ Mainz, Dept Internal Med 1, Univ Med Ctr, D-55131 Mainz, Germany
[9] Univ Hosp Wurzburg, Dept Med 2, Div Hepatol, D-97080 Wurzburg, Germany
[10] Gastroenterol Hepatol Ctr, D-24105 Kiel, Germany
[11] Hop Brabois CHU Nancy, Hepatogastroenterol, F-54500 Vandoeuvre Les Nancy, France
[12] Gastroenterol, D-65189 Wiesbaden, Germany
[13] Hepatol, D-44623 Herne, Germany
[14] Infektiologikum, D-60596 Frankfurt, Germany
[15] BioPredictive, F-75007 Paris, France
[16] St Josefs Hosp, Dept Gastroenterol, D-65189 Wiesbaden, Germany
关键词
HBV; non-invasive fibrosis assessment; point shear wave elastography; acoustic radiation force impulse imaging; transient elastography; fibrotest; APRI; FIB-4; LIVER STIFFNESS MEASUREMENT; CHRONIC HEPATITIS-B; SIMPLE NONINVASIVE INDEX; TRANSIENT ELASTOGRAPHY; VIRUS-INFECTION; OUTCOMES; PREDICT; HBSAG;
D O I
10.3390/jcm8122101
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.
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页数:11
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