The extrachromosomal elements of the Naegleria genus: How little we know

被引：5
|
作者：
Nguyen, B. T. [1 ]
Chapman, N. M. [2 ]
Tracy, S. [2 ]
Drescher, K. M. [1 ]
机构：
[1] Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, 2500 Calif Plaza,Criss II,Room 424, Omaha, NE 68178 USA
[2] Univ Nebraska, Med Sch, Dept Pathol & Microbiol, Omaha, NE 68182 USA
来源：
PLASMID | 2021年 / 115卷
关键词：
RIBOSOMAL-RNA GENES; INTERNAL TRANSCRIBED SPACERS; DNA-REPLICATION ORIGINS; GROUP-I INTRONS; PATHOGENICITY FACTORS; SEQUENCE; GENOME; RDNA; CHROMOSOME; EVOLUTION;
D O I：
10.1016/j.plasmid.2021.102567
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
There are currently 47 characterized species in the Naegleria genus of free-living amoebae. Each amoeba has thousands of extrachromosomal elements that are closed circular structures comprised of a single ribosomal DNA (rDNA) copy and a large non-rDNA sequence. Despite the presence of putative open reading frames and introns, ribosomal RNA is the only established transcript. A single origin of DNA replication (ori) has been mapped within the non-rDNA sequence for one species (N. gruberi), a finding that strongly indicates that these episomes replicate independently of the cell's chromosomal DNA component. This article reviews that which has been published about these interesting DNA elements and by analyzing available sequence data, discusses the possibility that different phylogenetically related clusters of Naegleria species individually conserve ori structures and suggests where the rRNA promoter and termination sites may be located.
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页数：7
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