Synthesis and characterization of curcumin loaded PLA-Hyperbranched polyglycerol electrospun blend for wound dressing applications

被引：159

作者：

Perumal, Govindaraj ^{[1
]}

Pappuru, Sreenath ^{[2
]}

Chakraborty, Debashis ^{[2
]}

Nandkumar, A. Maya ^{[3
]}

Chand, Dillip Kumar ^{[2
]}

Doble, Mukesh ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Biotechnol, Bhupat & Jyoti Mehta Sch Biosci, Madras 600036, Tamil Nadu, India

[2] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India

[3] Sree Chitra Tirunal Inst Med Sci & Technol, Div Microbial Technol, Biomed Technol Wing, Thiruvananthapuram 695012, Kerala, India

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 76卷

关键词：

Curcumin; HPG; PLA; Electrospinning; Nanofibers; Wound dressing; CHEMOPREVENTIVE AGENT; IN-VITRO; NANOFIBERS; RELEASE; FIBERS;

D O I：

10.1016/j.msec.2017.03.200

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

This study is aimed to develop curcumin (Cur) incorporated electrospun nanofibers of a blend of poly (lactic acid) (PLA) and hyperbranched polyglycerol (HPG) for wound healing applications. Both the polymers are synthesized and fabricated by electrospinning technique. The produced nanofibers were characterized by Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Colorimetry (DSC) and Thermogravimetric Analysis (TGA). Electrospun scaffolds (PLA/HPG/Cur) exhibits very high hydrophilicity, high swelling and drug uptake and promotes better cell viability, adhesion and proliferation when compared to PLA/Cur electrospun nanofibers. Biodegradation study revealed that the morphology of the nanofibers were unaffected even after 14 days immersion in Phosphate Buffered Saline. In vitro scratch assay indicates that migration of the cells in the scratch treated with PLA/HPG/Cur is complete within 36 h. These results suggest that PLA/HPG/Cur nanofibers can be a potential wound patch dressing for acute and chronic wound applications. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1196 / 1204

页数：9

共 51 条

[1] PHARMACOLOGY OF CURCUMA-LONGA [J].

AMMON, HPT ;

WAHL, MA .

PLANTA MEDICA, 1991, 57 (01) :1-7

[2]

[Anonymous], [No title captured]

[3]

Atala A, 2011, PRINCIPLES OF REGENERATIVE MEDICINE, 2ND EDITION, P1

[4]

Bainbridge P, 2013, J WOUND CARE, V22, P407

[5]

Baum CL, 2005, DERMATOL SURG, V31, P674

[6] Cell adhesion and proliferation on hydrophilic dendritically modified surfaces [J].

Benhabbour, Soumya R. ;

Sheardown, Heather ;

Adronov, Alex .

BIOMATERIALS, 2008, 29 (31) :4177-4186

[7] Electrospun Poly(L-lactide)/Poly(ε-caprolactone) Blend Nanofibrous Scaffold: Characterization and Biocompatibility with Human Adipose-Derived Stem Cells [J].

Chen, Liang ;

Bai, Yi ;

Liao, Guiying ;

Peng, Ejun ;

Wu, Bolin ;

Wang, Yuxi ;

Zeng, Xiaoyong ;

Xie, Xiaolin .

PLOS ONE, 2013, 8 (08)

[8] Preparation and Blood Compatibility of Electrospun PLA/Curcumin Composite Membranes [J].

Chen, Yan ;

Lin, Jie ;

Wan, Yuqin ;

Fei, Yanna ;

Wang, Hongbo ;

Gao, Weidong .

FIBERS AND POLYMERS, 2012, 13 (10) :1254-1258

[9]

Cheng AL, 2001, ANTICANCER RES, V21, P2895

[10] The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles [J].

Deng, Yang ;

Saucier-Sawyer, Jennifer K. ;

Hoimes, Christopher J. ;

Zhang, Junwei ;

Seo, Young-Eun ;

Andrejecsk, Jillian W. ;

Saltzman, W. Mark .

BIOMATERIALS, 2014, 35 (24) :6595-6602

← 1 2 3 4 5 6 →