Evaluation of K-RAS gene in colorectal cancer

被引：0

作者：

Okulczyk, B

Piotrowski, Z

Kovalchuk, O

Niklinski, J

Chyczewski, L

机构：

[1] Med Acad Bialystok, Dept Gen Surg 2, PL-15276 Bialystok, Poland

[2] Med Acad Bialystok, Dept Clin Mol Biol, PL-15276 Bialystok, Poland

[3] Med Acad Bialystok, Dept Thorac Surg, PL-15276 Bialystok, Poland

来源：

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2003年 / 41卷 / 02期

关键词：

colorectal cancer; K-RAS;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the study was to assess the prevalence of K-RAS gene mutations in colorectal cancer and their role in diagnosis and prognosis. The study involved 36 patients with colorectal cancer at different stages of the disease progression. and with different histopathologic grading. Mutations of codon 12 of K-RAS gene investigated using PCR-RFLP technique were found in 15 patients (41.67%). Although no statistically significant correlation was observed between the disease progression, histopathologic findings, gender and age, we suppose that assessment of K-RAS gene mutations might be of clinical value in the prognosis of colorectal cancer.

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页码：97 / 100

页数：4

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