Clonal spread of group A Streptococcus with the new type of erythromycin resistance

被引:75
作者
Kataja, J
Huovinen, P
Muotiala, A
Vuopio-Varkila, J
Efstratiou, A
Hallas, G
Seppälä, H
机构
[1] Natl Publ Hlth Inst, Antimicrobial Res Lab, FIN-20521 Turku, Finland
[2] Natl Publ Hlth Inst, Dept Bacteriol, Helsinki, Finland
[3] Cent Publ Hlth Lab, System Infect Lab, London NW9 5HT, England
关键词
D O I
10.1086/517809
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In 1990, a new type of erythromycin resistance phenotype, designated NR, was found in group A streptococcus (GAS) in Finland. In the present study, the distribution of GAS isolates with this and other erythromycin-resistance phenotypes was surveyed in Finland, and the clonality of the isolates was explored, Of 4179 GAS isolates collected from all over Finland, 695 (17%) were resistant to erythromycin, and 82% of these had the NR phenotype. Of a group of 96 isolates with the NR phenotype from different areas, 91% was T4 serotype, opacity factor-positive. The majority of these isolates were studied further: All were M4 serotype and 88% were of one clonal origin in genetic analyses. Thus, one single clone predominates among erythromycin-resistant GAS in Finland. This clone is of T4M4 serotype and mediates the new type of erythromycin resistance, characterized by the NR phenotype.
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页码:786 / 789
页数:4
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