4G/5G promoter PAI-1 gene polymorphism is associated with plasmatic PAI-1 activity in Italians: A model of gene-environment interaction

被引：87

作者：

Burzotta, F

Di Castelnuovo, A

Amore, C

D'Orazio, A

Di Bitondo, R

Donati, MB

Iacoviello, L ^{[1
]}

机构：

[1] Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Angela Valenti Lab Thrombosis Pharmacol, Dept Vasc Med & Pharmacol, I-66030 Santa Maria Imbaro, Italy

[2] TNO, IVVO, Gaubius Lab, NL-2300 AK Leiden, Netherlands

来源：

THROMBOSIS AND HAEMOSTASIS | 1998年 / 79卷 / 02期

关键词：

D O I：

10.1055/s-0037-1614991

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The PAI-1 gene promoter 4G/5G polymorphism was found to be associated with plasma PAI-1 activity in Northern and Central Europe populations, but no data are available on the association between this polymorphism and PAI-1 levels in Southern Europe countries (such as Italy) where the incidence of ischemic disorders is lower. This study shows that among populations with different incidence of atherothrombotic disorders the 4G/5G PAI-1 gene promoter polymorphism has the same importance in the regulation of plasma PAI-1 activity. Moreover, we have analysed some gene environmental interactions: the correlation between PAI-1 and cholesterol in non dyslipidemic subjects and the correlation between PAI-1 activity and tryglicerides in dyslipidemic subjects differed according to the 4G/5G genotype class. Thus, our findings suggest that, among subjects with or without metabolic disorders such as dyslipidemia, completely different gene-environment interactions may occur.

引用

页码：354 / 358

页数：5

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