Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2

被引：16

作者：

Tang Wen-Zhao ^{[1
,2
,3
]}

Wang Ying-Ai ^{[1
]}

Gao Tian-Yang ^{[1
]}

Wang Xiao-Jing ^{[1
]}

Zhao Yun-Xue ^{[4
]}

机构：

[1] Shandong Acad Med Sci, Inst Mat Med, Key Lab Biotech Drugs, Minist Hlth,Key Lab Rare & Uncommon Dis Shandong, Jinan 250062, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

[4] Shandong Univ, Sch Med, Dept Pharmacol, Jinan 250012, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2017年 / 15卷 / 05期

关键词：

Paulownia catalpifolia Gong Tong; C-geranylated flavonoids; Paucatalinone C; HPLC-DAD-ESI-MS/MS; Anti-aging effects; 2BS cells; TOMENTOSA FRUITS; FLAVANONES; INHIBITION;

D O I：

10.1016/S1875-5364(17)30059-6

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C (1) and five known C-geranylated flavanones (2-6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH2Cl2 extract of P. catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H2O2. Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C-geranylated flavonoids. Diplacone (3) and paucatalinone A (5) were the potent anti-aging agents in the premature senescent 2BS cells induced by H2O2 and the C-geranyl substituent may be an important factor because of its lipophilic character.

引用

页码：384 / 391

页数：8

共 21 条

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