Antimicrobial and antileishmanial activities of hypocrellins A and B

被引：123

作者：

Ma, GY

Khan, SI

Jacob, MR

Tekwani, BL

Li, ZQ

Pasco, DS

Walker, LA

Khan, LA ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA

[4] Yunnan Univ, Expt Ctr, Kunming, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 11期

关键词：

D O I：

10.1128/AAC.48.11.4450-4452.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antileishmanial activity, while hypocrellin B was only moderately active. These results of promising antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.

引用

页码：4450 / 4452

页数：3

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