Circadian NAD(P)(H) cycles in cell metabolism

被引:13
作者
Levine, Daniel C. [1 ]
Ramsey, Kathryn M. [1 ]
Bass, Joseph [1 ,2 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Endocrinol, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Med, Dept Neurobiol, 303 East Super St Lurie 7-107, Chicago, IL 60611 USA
关键词
Circadian clock; Metabolism; Sirtuins; Aging; Nicotinamide adenine dinucleotide(NAD plus ); NICOTINAMIDE-ADENINE-DINUCLEOTIDE; GENE-EXPRESSION; FOOD-INTAKE; CLOCK GENE; LIFE-SPAN; CALORIE RESTRICTION; ACID NICOTINAMIDE; PERIOD LOCUS; REDOX STATE; DNA-BINDING;
D O I
10.1016/j.semcdb.2021.07.008
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Intrinsic circadian clocks are present in all forms of photosensitive life, enabling daily anticipation of the light/ dark cycle and separation of energy storage and utilization cycles on a 24-h timescale. The core mechanism underlying circadian rhythmicity involves a cell-autonomous transcription/translation feedback loop that in turn drives rhythmic organismal physiology. In mammals, genetic studies have established that the core clock plays an essential role in maintaining metabolic health through actions within both brain pacemaker neurons and peripheral tissues and that disruption of the clock contributes to disease. Peripheral clocks, in turn, can be entrained by metabolic cues. In this review, we focus on the role of the nucleotide NAD(P)(H) and NAD+dependent sirtuin deacetylases as integrators of circadian and metabolic cycles, as well as the implications for this interrelationship in healthful aging.
引用
收藏
页码:15 / 26
页数:12
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