Establishment of human hepatocellular carcinoma CAM xenograft model and observation of angiogenesis characteristics

被引：0

作者：

Lv, Xiang ^{[1
]}

Ling, Li ^{[2
]}

Xia, Ying ^{[1
]}

Xu, Yan-Feng ^{[1
]}

Hou, Feng-Gang ^{[1
]}

Ren, Jian-Lin ^{[1
]}

Zhang, Xiao-Feng ^{[1
]}

Li, Yan ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Hepatoma; chick chorioallantoic membrane; models; animal; angiogenesis; EMBRYO CHORIOALLANTOIC MEMBRANE;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To investigate the establishing method of human hepatoma cell line Bel-7402 CAM transplantation model and to observe and analyze the characteristics of angiogenesis. Different concentrations of human hepatoma Bel-7402 cells were inoculated on chick embryo chorioallantoic membrane (CAM) to observe CAM tumor survival factors, tumor growth characteristics and angiogenesis. Human hepatocellular carcinoma CAM xenograft model was established. In the model, tumor was easy to grow, with a strong angiogenic effect. The model is easy to copy, and can dynamically observe HCC angiogenesis process, which can be used to study the biological behavior of HCC and screen drugs.

引用

页码：3698 / 3703

页数：6

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