Synthesis, crystal structures and cytotoxicities of some transition metal complexes with N-[2-{(pyridin-2-ylmethylidene)amino}ethyl]acetamide

被引：27

作者：

Zhao, Xinxin ^{[1
]}

Lee, Peter Peng-Foo ^{[1
]}

Yan, Yaw-Kai ^{[1
]}

Chu, Chit-Kay ^{[1
]}

机构：

[1] Nanyang Technol Univ, Natl Inst Educ, Singapore 637616, Singapore

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2007年 / 101卷 / 02期

关键词：

metal complex; anticancer activity; MOLT-4; leukemia; MCF-7 breast cancer;

D O I：

10.1016/j.jinorgbio.2006.10.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and spectroscopic (IR, H-1 and C-13 NMR) characterization of new complexes of Pt(II), Pd(11), Cu(11), and Hg(11) with the Schiff base ligand MeCONHCH2CH2N=CHPy (L) (Py = pyridine) are reported, together with studies on the cytotoxicities of these complexes, L and [ReBr(COWL)] against human leukemia (MOLT-4), breast cancer (MCF-7) and Chang Liver (non-cancerous) cells. The crystal structures of [Pt(L)Cl-2](2), [Cu(L)Cl-2](4) and [Hg(L)Cl-2](2) (5) are also reported. Of the complexes studied, [Cu(L)Cl-2](4) was identified as the most cytotoxic active derivative against cells of neoplastic origin (MOLT-4, and MCF-7), while having low toxicity on cells of benign origin (Chang Liver). (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：321 / 328

页数：8

共 32 条

[1] CRYSTAL-STRUCTURE OF A DIMERIC 1-METHYLCYTOSINE MERCURIC-CHLORIDE COMPLEX [J].

AUTHIERMARTIN, M ;

BEAUCHAMP, AL .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1977, 55 (07) :1213-1217

[2] Stereoselective coordination of prochiral olefins to asymmetric platinum(II) complexes and a diplatinum(II) complex with a single unsupported halide bridge [J].

Baar, CR ;

Jenkins, HA ;

Jennings, MC ;

Yap, GPA ;

Puddephatt, RJ .

ORGANOMETALLICS, 2000, 19 (23) :4870-4877

[3] A phase I clinical and pharmacological study of cis-diamminedichloro(2-methylpyridine) platinum II (AMD473) [J].

Beale, P ;

Judson, I ;

O'Donnell, A ;

Trigo, J ;

Rees, C ;

Raynaud, F ;

Turner, A ;

Simmons, L ;

Etterley, L .

BRITISH JOURNAL OF CANCER, 2003, 88 (07) :1128-1134

[4] Recent advances in management of small-cell lung cancer [J].

Chua, YJ ;

Steer, C ;

Yip, C .

CANCER TREATMENT REVIEWS, 2004, 30 (06) :521-543

[5] Synthesis, characterization, and cytotoxicities of platinum(II) complexes bearing pyridinecarboxaldimines containing bulky aromatic groups [J].

Conrad, ML ;

Enman, JE ;

Scales, SJ ;

Zhang, HW ;

Vogels, CM ;

Saleh, MT ;

Decken, A ;

Westcott, SA .

INORGANICA CHIMICA ACTA, 2005, 358 (01) :63-69

[6]

DEAN PAW, 1978, PROG INORG CHEM, V24, P109

[7] VIBRATIONAL ANALYSIS OF OXAMIDES - CHARACTERISTIC PATTERN OF AMIDES IN IR AND RAMAN-SPECTRA [J].

DESSEYN, HO ;

VANDERVEKEN, BJ ;

HERMAN, MA .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 1977, 33 (6-7) :633-641

[8]

DURON RR, 2002, PHARM BIOL, V40, P440

[9]

FAN D, 2003, J CHEM SOC DA, P3376

[10] Antitumoral activity of non-platinum xanthate complexes [J].

Friebolin, W ;

Schilling, G ;

Zöller, M ;

Amtmann, E .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (25) :7925-7931

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