Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection

被引：92
作者：
Ben-Ami, Ronen [3 ]
Lewis, Russell E. [2 ]
Kontoyiannis, Dimitrios P. [1 ,2 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Unit 1460, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA
[2] Univ Houston, Coll Pharm, Houston, TX 77030 USA
[3] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Infect Dis Unit, IL-69978 Tel Aviv, Israel
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 150卷 / 04期
关键词：
Aspergillus fumigatus; pathogenesis; immunosuppressed state; INVASIVE PULMONARY ASPERGILLOSIS; GLIOTOXIN INDUCES APOPTOSIS; TOLL-LIKE RECEPTORS; PROTEIN-KINASE-A; IN-VITRO; IMMUNE RECOGNITION; ALKALINE PROTEASE; RISK-FACTOR; ENDOTHELIAL-CELLS; RHIZOPUS-ORYZAE;
D O I：
10.1111/j.1365-2141.2010.08283.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P>Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and the complex interplay between host and microbial factors. In this review, we outline current concepts of immune recognition and evasion, angioinvasion and angiogenesis, secondary metabolism and the fungal stress response, and their respective roles in this often lethal infection.
引用
收藏
页码：406 / 417
页数：12
相关论文
共 106 条
  • [11] LaeA, a regulator of morphogenetic fungal virulence factors
    Bok, JW
    Balajee, SA
    Marr, KA
    Andes, D
    Nielsen, KF
    Frisvad, JC
    Keller, NP
    [J]. EUKARYOTIC CELL, 2005, 4 (09) : 1574 - 1582
  • [12] Early neutrophil recruitment and aggregation in the murine lung inhibit germination of Aspergillus fumigatus conidia
    Bonnett, Colin R.
    Cornish, E. Jean
    Harmsen, Allen G.
    Burritt, James B.
    [J]. INFECTION AND IMMUNITY, 2006, 74 (12) : 6528 - 6539
  • [13] Immune recognition -: A new receptor for β-glucans
    Brown, GD
    Gordon, S
    [J]. NATURE, 2001, 413 (6851) : 36 - 37
  • [14] Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA
    Bruns, Sandra
    Kniemeyer, Olaf
    Hasenberg, Mike
    Aimanianda, Vishukumar
    Nietzsche, Sandor
    Thywissen, Andreas
    Jeron, Andreas
    Latge, Jean-Paul
    Brakhage, Axel A.
    Gunzer, Matthias
    [J]. PLOS PATHOGENS, 2010, 6 (04) : 1 - 18
  • [15] Th1 and Th2 cytokines in mice with invasive aspergillosis
    Cenci, E
    Perito, S
    Enssle, KH
    Mosci, P
    Latge, JP
    Romani, L
    Bistoni, F
    [J]. INFECTION AND IMMUNITY, 1997, 65 (02) : 564 - 570
  • [16] Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity
    Chai, Louis Y. A.
    van de Veerdonk, Frank
    Marijnissen, Renoud J.
    Cheng, Shih-Chin
    Khoo, Ai Leng
    Hectors, Magda
    Lagrou, Katrien
    Vonk, Alieke G.
    Maertens, Johan
    Joosten, Leo A. B.
    Kullberg, Bart-Jan
    Netea, Mihai G.
    [J]. IMMUNOLOGY, 2010, 130 (01) : 46 - 54
  • [17] Modulation of Toll-Like Receptor 2 (TLR2) and TLR4 Responses by Aspergillus fumigatus
    Chai, Louis Y. A.
    Kullberg, Bart Jan
    Vonk, Alieke G.
    Warris, Adilia
    Cambi, Alessandra
    Latge, Jean-Paul
    Joosten, Leo A. B.
    van der Meer, Jos W. M.
    Netea, Mihai G.
    [J]. INFECTION AND IMMUNITY, 2009, 77 (05) : 2184 - 2192
  • [18] Aspergillus fumigatus stimulates leukocyte adhesion molecules and cytokine production by endothelial cells in vitro and during invasive pulmonary disease
    Chiang, Lisa Y.
    Sheppard, Donald C.
    Gravelat, Fabrice N.
    Patterson, Thomas F.
    Filler, Scott G.
    [J]. INFECTION AND IMMUNITY, 2008, 76 (08) : 3429 - 3438
  • [19] Discovery of gliotoxin as a new small molecule targeting thioredoxin redox system
    Choi, Hee Shim
    Shim, Joong Sup
    Kim, Ju-A
    Kang, Sang Won
    Kwon, Ho Jeong
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 359 (03) : 523 - 528
  • [20] LACK OF VESSEL WALL ELASTOLYSIS IN HUMAN INVASIVE PULMONARY ASPERGILLOSIS
    DENNING, DW
    WARD, PN
    FENELON, LE
    BENBOW, EW
    [J]. INFECTION AND IMMUNITY, 1992, 60 (12) : 5153 - 5156
12345678910