Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection

被引：92
作者：
Ben-Ami, Ronen [3 ]
Lewis, Russell E. [2 ]
Kontoyiannis, Dimitrios P. [1 ,2 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Unit 1460, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA
[2] Univ Houston, Coll Pharm, Houston, TX 77030 USA
[3] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Infect Dis Unit, IL-69978 Tel Aviv, Israel
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 150卷 / 04期
关键词：
Aspergillus fumigatus; pathogenesis; immunosuppressed state; INVASIVE PULMONARY ASPERGILLOSIS; GLIOTOXIN INDUCES APOPTOSIS; TOLL-LIKE RECEPTORS; PROTEIN-KINASE-A; IN-VITRO; IMMUNE RECOGNITION; ALKALINE PROTEASE; RISK-FACTOR; ENDOTHELIAL-CELLS; RHIZOPUS-ORYZAE;
D O I：
10.1111/j.1365-2141.2010.08283.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P>Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and the complex interplay between host and microbial factors. In this review, we outline current concepts of immune recognition and evasion, angioinvasion and angiogenesis, secondary metabolism and the fungal stress response, and their respective roles in this often lethal infection.
引用
收藏
页码：406 / 417
页数：12
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