Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection

被引：95

作者：

Ben-Ami, Ronen ^{[3
]}

Lewis, Russell E. ^{[2
]}

Kontoyiannis, Dimitrios P. ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Unit 1460, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA

[2] Univ Houston, Coll Pharm, Houston, TX 77030 USA

[3] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Infect Dis Unit, IL-69978 Tel Aviv, Israel

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 150卷 / 04期

关键词：

Aspergillus fumigatus; pathogenesis; immunosuppressed state; INVASIVE PULMONARY ASPERGILLOSIS; GLIOTOXIN INDUCES APOPTOSIS; TOLL-LIKE RECEPTORS; PROTEIN-KINASE-A; IN-VITRO; IMMUNE RECOGNITION; ALKALINE PROTEASE; RISK-FACTOR; ENDOTHELIAL-CELLS; RHIZOPUS-ORYZAE;

D O I：

10.1111/j.1365-2141.2010.08283.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and the complex interplay between host and microbial factors. In this review, we outline current concepts of immune recognition and evasion, angioinvasion and angiogenesis, secondary metabolism and the fungal stress response, and their respective roles in this often lethal infection.

引用

页码：406 / 417

页数：12

共 106 条

[1] Surface hydrophobin prevents immune recognition of airborne fungal spores [J].

Aimanianda, Vishukumar ;

Bayry, Jagadeesh ;

Bozza, Silvia ;

Kniemeyer, Olaf ;

Perruccio, Katia ;

Elluru, Sri Ramulu ;

Clavaud, Cecile ;

Paris, Sophie ;

Brakhage, Axel A. ;

Kaveri, Srini V. ;

Romani, Luigina ;

Latge, Jean-Paul .

NATURE, 2009, 460 (7259) :1117-1121

[2] Breakthrough Aspergillus fumigatus and Candida albicans Double Infection during Caspofungin Treatment: Laboratory Characteristics and Implication for Susceptibility Testing [J].

Arendrup, Maiken Cavling ;

Garcia-Effron, Guillermo ;

Buzina, Walter ;

Mortensen, Klaus Leth ;

Reiter, Nanna ;

Lundin, Christian ;

Jensen, Henrik Elvang ;

Lass-Florl, Cornelia ;

Perlin, David S. ;

Bruun, Brita .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (03) :1185-1193

[3] Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis [J].

Balloy, V ;

Huerre, M ;

Latgé, JP ;

Chignard, M .

INFECTION AND IMMUNITY, 2005, 73 (01) :494-503

[4] The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo [J].

Bellocchio, S ;

Montagnoli, C ;

Bozza, S ;

Gaziano, R ;

Rossi, G ;

Mambula, SS ;

Vecchi, A ;

Mantovani, A ;

Levitz, SM ;

Romani, L .

JOURNAL OF IMMUNOLOGY, 2004, 172 (05) :3059-3069

[5] Cutaneous Model of Invasive Aspergillosis [J].

Ben-Ami, Ronen ;

Lewis, Russell E. ;

Leventakos, Konstantinos ;

Latge, Jean-Paul ;

Kontoyiannis, Dimitrios P. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (05) :1848-1854

[6] Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites [J].

Ben-Ami, Ronen ;

Lewis, Russell E. ;

Leventakos, Konstantinos ;

Kontoyiannis, Dimitrios P. .

BLOOD, 2009, 114 (26) :5393-5399

[7] A Regulator of Aspergillus fumigatus Extracellular Proteolytic Activity Is Dispensable for Virulence [J].

Bergmann, Anna ;

Hartmann, Thomas ;

Cairns, Timothy ;

Bignell, Elaine M. ;

Krappmann, Sven .

INFECTION AND IMMUNITY, 2009, 77 (09) :4041-4050

[8] Aspergillus fumigatus conidia inhibit tumour necrosis factor- or staurosporine-induced apoptosis in epithelial cells [J].

Berkova, N ;

Lair-Fulleringer, S ;

Féménia, F ;

Huet, D ;

Wagner, MC ;

Gorna, K ;

Tournier, F ;

Ibrahim-Granet, O ;

Guillot, J ;

Chermette, R ;

Boireau, P ;

Latgé, JP .

INTERNATIONAL IMMUNOLOGY, 2006, 18 (01) :139-150

[9] Interactions of Aspergillus fumigatus with endothelial cells:: internalization, injury, and stimulation of tissue factor activity [J].

Bezerra, LML ;

Filler, SG .

BLOOD, 2004, 103 (06) :2143-2149

[10] Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation [J].

Bochud, Pierre-Yves ;

Chien, Jason W. ;

Marr, Kieren A. ;

Leisenring, Wendy M. ;

Upton, Arlo ;

Janer, Marta ;

Rodrigues, Stephanie D. ;

Li, Sarah ;

Hansen, John A. ;

Zhao, Lue Ping ;

Aderem, Alan ;

Boeckh, Michael .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (17) :1766-1777

← 1 2 3 4 5 6 7 8 9 10 →