Allosteric ACTion: the varied ACT domains regulating enzymes of amino-acid metabolism

被引：64

作者：

Lang, Eric J. M. ^{[1
]}

Cross, Penelope J. ^{[1
]}

Mittelstaedt, Gerd ^{[1
]}

Jameson, Geoffrey B. ^{[2
]}

Parker, Emily J. ^{[1
]}

机构：

[1] Univ Canterbury, Biomol Interact Ctr, Maurice Wilkins Ctr, Dept Chem, Christchurch 1, New Zealand

[2] Massey Univ, Inst Fundamental Sci, Palmerston North, New Zealand

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2014年 / 29卷

关键词：

CRYSTAL-STRUCTURE; ASPARTATE KINASE; STRUCTURAL BASIS; SYNTHASE; SUBUNIT; INHIBITION; MECHANISM; PROTEINS; MODEL;

D O I：

10.1016/j.sbi.2014.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Allosteric regulation of enzyme activity plays important metabolic roles. Here we review the allostery of enzymes of amino-acid metabolism conferred by a discrete domain known as the ACT domain. This domain of 60-70 residues has a beta alpha beta beta alpha beta topology leading to a four-stranded beta(4)beta(1)beta(3)beta(2) antiparallel sheet with two antiparallel helices on one face. Extensive sequence variation requires a combined sequence/ structure/function analysis for identification of the ACT domain. Common features include highly varied modes of self-association of ACT domains, ligand binding at domain interfaces, and transmittal of allosteric signals through conformational changes and/or the manipulation of quaternary equilibria. A recent example illustrates the relatively facile adoption of this versatile module of allostery by gene fusion.

引用

页码：102 / 111

页数：10

共 38 条

[1] Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches [J].

Aravind, L ;

Koonin, EV .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 287 (05) :1023-1040

[2] Allosteric regulation in Acetohydroxyacid Synthases (AHASs) - Different structures and kinetic behavior in isozymes in the same organisms [J].

Barak, Ze'ev ;

Chipman, David M. .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2012, 519 (02) :167-174

[3] Allostery and the Monod-Wyman-Changeux Model After 50 Years [J].

Changeux, Jean-Pierre .

ANNUAL REVIEW OF BIOPHYSICS, VOL 41, 2012, 41 :103-133

[4] From cyanobacteria to plants: conservation of PII functions during plastid evolution [J].

Chellamuthu, Vasuki Ranjani ;

Alva, Vikram ;

Forchhammer, Karl .

PLANTA, 2013, 237 (02) :451-462

[5] Study and reengineering of the binding sites and allosteric regulation of biosynthetic threonine deaminase by isoleucine and valine in Escherichia coli [J].

Chen, Lin ;

Chen, Zhen ;

Zheng, Ping ;

Sun, Jibin ;

Zeng, An-Ping .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2013, 97 (07) :2939-2949

[6] Allosteric Activation and Contrasting Properties of L-Serine Dehydratase Types 1 and 2 [J].

Chen, Shawei ;

Xu, Xiao Lan ;

Grant, Gregory A. .

BIOCHEMISTRY, 2012, 51 (26) :5320-5328

[7] The ACT domain family [J].

Chipman, DM ;

Shaanan, B .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2001, 11 (06) :694-700

[8] Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis [J].

Cho, Y ;

Sharma, V ;

Sacchettini, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) :8333-8339

[9] Allosteric inhibitor specificity of Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase [J].

Cross, Penelope J. ;

Parker, Emily J. .

FEBS LETTERS, 2013, 587 (18) :3063-3068

[10] Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain [J].

Cross, Penelope J. ;

Allison, Timothy M. ;

Dobson, Renwick C. J. ;

Jameson, Geoffrey B. ;

Parker, Emily J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (06) :2111-2116

← 1 2 3 4 →