Ionic liquid-based compound droplet microfluidics for 'on-drop' separations and sensing

被引：40

作者：

Barikbin, Zahra ^{[1
]}

Rahman, Md. Taifur ^{[1
]}

Parthiban, Pravien ^{[2
]}

Rane, Anandkumar S. ^{[1
]}

Jain, Vaibhav ^{[1
]}

Duraiswamy, Suhanya ^{[2
]}

Lee, S. H. Sophia ^{[1
]}

Khan, Saif A. ^{[1
,2
]}

机构：

[1] Singapore MIT Alliance, Singapore 117576, Singapore

[2] Dept Chem & Biomol Engn, Singapore 117576, Singapore

来源：

LAB ON A CHIP | 2010年 / 10卷 / 18期

关键词：

WHOLE-BLOOD; FLUID-FLOW; SCALE; PARTICLES; CHIP; LITHOGRAPHY; EMULSIONS; KINETICS; BUBBLES; SYSTEMS;

D O I：

10.1039/c004853d

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a new and general scheme for analytical applications of droplet-based microfluidics in which flowing droplets function not only as isolated reaction flasks, but are also capable of on-drop separation and sensing. To demonstrate this, we choose ionic liquids as designer fluids whose chemical and physical properties can be tailored in task-specific fashion. We create aqueous-ionic liquid compound droplets with tunable structures using an imidazolium-based ionic liquid, and present two analytical applications-separation of a binary aqueous mixture of organic dyes and dynamic pH sensing-to highlight the salient features of this scheme. By combining designer fluids with designer microfluidic emulsions, our work opens up a rich space of exploration for analytical microfluidics.

引用

页码：2458 / 2463

页数：6

共 67 条

[1] Enhancement of reaction rates by segmented fluid flow in capillary scale reactors [J].

Ahmed, Batoul ;

Barrow, David ;

Wirth, Thomas .

ADVANCED SYNTHESIS & CATALYSIS, 2006, 348 (09) :1043-1048

[2] Modeling shapes and dynamics of confined bubbles [J].

Ajaev, VS ;

Homsy, GM .

ANNUAL REVIEW OF FLUID MECHANICS, 2006, 38 :277-307

[3] Phase knowledge enables rational screens for protein crystallization [J].

Anderson, Megan J. ;

Hansen, Carl L. ;

Quake, Stephen R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16746-16751

[4] Microscale tipstreaming in a microfluidic flow focusing device [J].

Anna, Shelley L. ;

Mayer, Hans C. .

PHYSICS OF FLUIDS, 2006, 18 (12)

[5] Highly parallel measurements of interaction kinetic constants with a microfabricated optomechanical device [J].

Bates, Steven R. ;

Quake, Stephen R. .

APPLIED PHYSICS LETTERS, 2009, 95 (07)

[6] Hydrophobic, highly conductive ambient-temperature molten salts [J].

Bonhote, P ;

Dias, AP ;

Papageorgiou, N ;

Kalyanasundaram, K ;

Gratzel, M .

INORGANIC CHEMISTRY, 1996, 35 (05) :1168-1178

[7] Microfluidic systems for chemical kinetics that rely on chaotic mixing in droplets [J].

Bringer, MR ;

Gerdts, CJ ;

Song, H ;

Tice, JD ;

Ismagilov, RF .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2004, 362 (1818) :1087-1104

[8] High-temperature microfluidic synthesis of CdSe nanocrystals in nanoliter droplets [J].

Chan, EM ;

Alivisatos, AP ;

Mathies, RA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (40) :13854-13861

[9] Janus Particles Templated from Double Emulsion Droplets Generated Using Mcrofluidics [J].

Chen, Chia-Hung ;

Shah, Rhutesh K. ;

Abate, Adam R. ;

Weitz, David A. .

LANGMUIR, 2009, 25 (08) :4320-4323

[10] Microfluidic methods for generating continuous droplet streams [J].

Christopher, G. F. ;

Anna, S. L. .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2007, 40 (19) :R319-R336

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