Significant Association of Chitinase 3-like 1 Genotypes to Asthma Risk in Taiwan

被引：8

作者：

Chen, Guan-Liang ^{[1
,2
,3
]}

Wang, Shou-Cheng ^{[2
,3
]}

Shen, Te-Chun ^{[1
,4
,5
]}

Chang, Wen-Shin ^{[1
,4
]}

Lin, Chingju ^{[6
]}

Hsia, Te-Chun ^{[4
,5
]}

Bau, Da-Tian ^{[1
,4
,7
]}

Tsai, Chia-Wen ^{[1
,4
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[2] Taichung Armed Forces Gen Hosp, Div Chest Med, Taichung, Taiwan

[3] Natl Def Med Ctr, Taipei, Taiwan

[4] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, 2 Yuh Der Rd, Taichung 404, Taiwan

[5] China Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Taichung, Taiwan

[6] China Med Univ, Sch Med, Dept Physiol, Taichung, Taiwan

[7] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

IN VIVO | 2021年 / 35卷 / 02期

关键词：

Asthma; genotype; polymorphism; Taiwan; MAMMALIAN MEMBER; PROTEIN; YKL-40; IDENTIFICATION; BIOMARKER; CELLS;

D O I：

10.21873/invivo.12320

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Chitinase 3-like 1 (CHI3L1) is overexpressed in asthma, and negatively associated with forced expiratory volume in the first second. This study aimed at evaluating whether CHI3L1 genotypes affect asthma risk. Materials and Methods: The blood samples of 198 asthma patients and 453 control subjects were collected, and the genotypic patterns of CHI3L1-131C/G (rs4950928) and-247G/A (rs1262491437) were examined. Results: The percentages of CG and GG at CHI3L1-131C/G were 32.8% and 7.6% among the asthma cases, respectively, significantly higher than the 23.8% and 3.1% among the non-asthmatic healthy subjects (p for trend=0.0009). The allelic frequency distribution analysis showed that the G allele at CHI3L1 131C/G conferred a significantly higher asthma risk than the wild-type C allele (p<0.0001). The genotypic and allelic frequency analyses for CHI3L1-247G/A did not show any significant difference. Conclusion: The G allele at CHI3L1-131C/G serves as a biomarker in determining personal susceptibility to asthma in Taiwan.

引用

页码：799 / 803

页数：5

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