The m6A epitranscriptome on neural development and degeneration

被引：59

作者：

Yen, Ya-Ping ^{[1
]}

Chen, Jun-An ^{[1
]}

机构：

[1] Acad Sinica, Inst Mol Biol, Taipei 11529, Taiwan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2021年 / 28卷 / 01期

关键词：

m(6)A; Epitranscriptome; RNA; Neural development; Neurodegeneration; MESSENGER-RNA METHYLATION; GENE-EXPRESSION; NUCLEAR-RNA; FAT MASS; BRAIN-DEVELOPMENT; POTENTIAL ROLE; N-6-METHYLADENOSINE; FTO; M6A; ASSOCIATION;

D O I：

10.1186/s12929-021-00734-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

N-6-methyladenosine (m(6)A) is the most prevalent, conserved, and abundant RNA modification of the mRNAs of most eukaryotes, including mammals. Similar to epigenetic DNA modifications, m(6)A has been proposed to function as a critical regulator for gene expression. This modification is installed by m(6)A methylation "writers" (Mettl3/Mettl14 methyltransferase complex), and it can be reversed by demethylase "erasers" (Fto and Alkbh5). Furthermore, m(6)A can be recognized by "readers" (Ythdf and Ythdc families), which may be interpreted to affect mRNA splicing, stability, translation or localization. Levels of m(6)A methylation appear to be highest in the brain, where it plays important functions during embryonic stem cell differentiation, brain development, and neurodevelopmental disorders. Depletion of the m(6)A methylation writer Mettl14 from mouse embryonic nervous systems prolongs cell cycle progression of radial glia and extends cortical neurogenesis into postnatal stages. Recent studies further imply that dysregulated m(6)A methylation may be significantly correlated with neurodegenerative diseases. In this review, we give an overview of m(6)A modifications during neural development and associated disorders, and provide perspectives for studying m(6)A methylation.

引用

页数：11

共 75 条

[1] Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy [J].

Aas, Aleksander ;

Isakson, Pauline ;

Bindesboll, Christian ;

Alemu, Endalkachew A. ;

Klungland, Arne ;

Simonsen, Anne .

PLOS ONE, 2017, 12 (03)

[2] HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events [J].

Alarcon, Claudio R. ;

Goodarzi, Hani ;

Lee, Hyeseung ;

Liu, Xuhang ;

Tavazoie, Saeed ;

Tavazoie, Sohail F. .

CELL, 2015, 162 (06) :1299-1308

[3] N6-methyladenosine marks primary microRNAs for processing [J].

Alarcon, Claudio R. ;

Lee, Hyeseung ;

Goodarzi, Hani ;

Halberg, Nils ;

Tavazoie, Sohail F. .

NATURE, 2015, 519 (7544) :482-+

[4] Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease [J].

Bateman, Randall J. ;

Xiong, Chengjie ;

Benzinger, Tammie L. S. ;

Fagan, Anne M. ;

Goate, Alison ;

Fox, Nick C. ;

Marcus, Daniel S. ;

Cairns, Nigel J. ;

Xie, Xianyun ;

Blazey, Tyler M. ;

Holtzman, David M. ;

Santacruz, Anna ;

Buckles, Virginia ;

Oliver, Angela ;

Moulder, Krista ;

Aisen, Paul S. ;

Ghetti, Bernardino ;

Klunk, William E. ;

McDade, Eric ;

Martins, Ralph N. ;

Masters, Colin L. ;

Mayeux, Richard ;

Ringman, John M. ;

Rossor, Martin N. ;

Schofield, Peter R. ;

Sperling, Reisa A. ;

Salloway, Stephen ;

Morris, John C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (09) :795-804

[5] m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells [J].

Batista, Pedro J. ;

Molinie, Benoit ;

Wang, Jinkai ;

Qu, Kun ;

Zhang, Jiajing ;

Li, Lingjie ;

Bouley, Donna M. ;

Lujan, Ernesto ;

Haddad, Bahareh ;

Daneshvar, Kaveh ;

Carter, Ava C. ;

Flynn, Ryan A. ;

Zhou, Chan ;

Lim, Kok-Seong ;

Dedon, Peter ;

Wernig, Marius ;

Mullen, Alan C. ;

Xing, Yi ;

Giallourakis, Cosmas C. ;

Chang, Howard Y. .

CELL STEM CELL, 2014, 15 (06) :707-719

[6] Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations [J].

Boissel, Sarah ;

Reish, Orit ;

Proulx, Karine ;

Kawagoe-Takaki, Hiroko ;

Sedgwick, Barbara ;

Yeo, Giles S. H. ;

Meyre, David ;

Golzio, Christelle ;

Molinari, Florence ;

Kadhom, Noman ;

Etchevers, Heather C. ;

Saudek, Vladimir ;

Farooqi, I. Sadaf ;

Froguel, Philippe ;

Lindahl, Tomas ;

O'Rahilly, Stephen ;

Munnich, Arnold ;

Colleaux, Laurence .

AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 85 (01) :106-111

[7] ANTIBODIES SPECIFIC FOR N-6-METHYLADENOSINE REACT WITH INTACT SNRNPS U2 AND U4/U6 [J].

BRINGMANN, P ;

LUHRMANN, R .

FEBS LETTERS, 1987, 213 (02) :309-315

[8] A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP [J].

Caglayan, Ahmet O. ;

Tuysuz, Beyhan ;

Coskun, Suleyman ;

Quon, Jennifer ;

Harmanci, Akdes S. ;

Baranoski, Jacob F. ;

Baran, Burcin ;

Erson-Omay, E. Zeynep ;

Henegariu, Octavian ;

Mane, Shrikant M. ;

Bilguvar, Kaya ;

Yasuno, Katsuhito ;

Gunel, Murat .

JOURNAL OF HUMAN GENETICS, 2016, 61 (05) :395-403

[9] Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain [J].

Chang, Mengqi ;

Lv, Hongyi ;

Zhang, Weilong ;

Ma, Chunhui ;

He, Xue ;

Zhao, Shunli ;

Zhang, Zhi-Wei ;

Zeng, Yi-Xin ;

Song, Shuhui ;

Niu, Yamei ;

Tong, Wei-Min .

OPEN BIOLOGY, 2017, 7 (09)

[10] Functional Roles of Long Non-coding RNAs in Motor Neuron Development and Disease [J].

Chen, Kuan-Wei ;

Chen, Jun-An .

JOURNAL OF BIOMEDICAL SCIENCE, 2020, 27 (01)

← 1 2 3 4 5 6 7 8 →