Structure based design:: Novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors

被引：33

作者：

Ghosh, AK

Krishnan, K

Walters, DE

Cho, WH

Cho, H

Koo, Y

Trevino, J

Holland, L

Buthod, J

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

[2] Finch Univ Hlth Sci Chicago Med Sch, Dept Biol Chem, N Chicago, IL 60064 USA

[3] IIT, Res Inst, Dept Life Sci, Chicago, IL 60616 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(98)00139-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel spirocyclic ethers were designed to function as nonpeptidal P-2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：979 / 982

页数：4

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