Structure based design:: Novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors

被引：33
作者：
Ghosh, AK
Krishnan, K
Walters, DE
Cho, WH
Cho, H
Koo, Y
Trevino, J
Holland, L
Buthod, J
机构：
[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA
[2] Finch Univ Hlth Sci Chicago Med Sch, Dept Biol Chem, N Chicago, IL 60064 USA
[3] IIT, Res Inst, Dept Life Sci, Chicago, IL 60616 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 08期
关键词：
D O I：
10.1016/S0960-894X(98)00139-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel spirocyclic ethers were designed to function as nonpeptidal P-2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：979 / 982
页数：4
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