Skin color independent assessment of aging using skin autofluorescence

被引：78

作者：

Koetsier, Marten ^{[1
]}

Nur, Erfan ^{[4
]}

Han Chunmao ^{[5
]}

Lutgers, Helen L. ^{[2
,6
]}

Links, Thera P. ^{[2
,6
]}

Smit, Andries J. ^{[3
]}

Rakhorst, Gerhard ^{[1
]}

Graaff, Reindert ^{[1
,2
,6
]}

机构：

[1] Univ Med Ctr Groningen, Dept Biomed Engn, NL-9713 AV Groningen, Netherlands

[2] Univ Med Ctr Groningen, Dept Endocrinol, NL-9713 AV Groningen, Netherlands

[3] Univ Med Ctr Groningen, Dept Med, NL-9713 AV Groningen, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Internal Med Haematol, NL-1105 AZ Amsterdam, Netherlands

[5] Zhejiang Univ, Coll Med, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China

[6] Univ Med Ctr Groningen, NL-9700 AD Groningen, Netherlands

来源：

OPTICS EXPRESS | 2010年 / 18卷 / 14期

关键词：

GLYCATION END-PRODUCTS; MONTE-CARLO-SIMULATION; FLUORESCENCE SPECTROSCOPY; DIFFUSE-REFLECTANCE; OPTICAL-PROPERTIES; HUMAN MELANIN; DISEASE; MARKER; PIGMENTATION; ACCUMULATION;

D O I：

10.1364/OE.18.014416

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Skin autofluorescence (AF) for the non-invasive assessment of the amount of accumulated tissue Advanced Glycation Endproducts (AGEs) increases with aging. In subjects with darker skin colors, measurements typically result in lower AF values than in subjects with fair skin colors, e. g. due to selective absorption by skin compounds. Our aim was to provide a new method for calculating skin AF, yielding values that are independent of skin color. The deviation of skin AF of healthy subjects with various darker skin types (N = 99) compared to reference values from Caucasians showed to be a function of various parameters that were derived from reflectance and emission spectra in the UV and visible range (adjusted R-2 = 80%). Validation of the new algorithm, based on these findings, in a separate dataset (N = 141) showed that results of skin AF can now be obtained to assess skin AGEs independently of skin color.

引用

页码：14416 / 14429

页数：14

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