Influence of design on bioactivity of novel CaSiO3-CaMg(SiO3)2 bioceramics: In vitro simulated body fluid test and thermodynamic simulation

被引：115
|
作者：
Sainz, M. A. [1 ]
Pena, P. [1 ]
Serena, S. [1 ]
Caballero, A. [1 ]
机构：
[1] CSIC, Inst Ceram & Vidrio, Madrid 28049, Spain
来源：
ACTA BIOMATERIALIA | 2010年 / 6卷 / 07期
关键词：
Diopside; Wollastonite; Microstructure; Bioactivity; Thermodynamic simulation; CALCIUM-PHOSPHATE CERAMICS; TRICALCIUM PHOSPHATE; BONE SUBSTITUTE; POROUS HYDROXYAPATITE; ELEVATED-TEMPERATURES; APATITE FORMATION; RABBITS; TISSUE; WOLLASTONITE; INTERFACE;
D O I：
10.1016/j.actbio.2010.01.003
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A new type of bioactive ceramic has been designed and obtained from high-temperature phase information from the wollastonite (CaSiO3)-diopside (CaMg(SiO3)(2)) phase equilibrium diagram. The selected composition was that corresponding to the eutectic point of the pseudobinary CaSiO3-CaMg(SiO3)(2) system. The sintering behaviour, phase evolution, microstructural changes and in vitro bioactivity of CaSiO3-CaMg(SiO3)(2) eutectic bioceramics were analysed by differential thermal analysis, X-ray diffraction, field emission scanning electron microscopy (FE-SEM) and image analysis. A simulation of the dissolution properties of the different materials studied, in water as well as in simulated body fluid (SBF), was also carried out by thermodynamic calculations, with the purpose of understanding the in vitro results obtained. The results demonstrate that the CaMg(SiO3)(2) is significantly less soluble than CaSiO3, developing an in situ porous structure (biomimetic porous bone material) with adequate biodegradation rate and stability strength when immersed in SBF. The influence of the microstructure (porosity, grain size and phase composition) on the in vitro bioactivity of the obtained bioceramics was also examined. (C) 2010 Acts Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：2797 / 2807
页数：11
相关论文
共 2 条
  • [1] Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition
    Garcia-Paez, Ismael H.
    Pena, Pilar
    Baudin, Carmen
    Angel Rodrigueza, M.
    Cordoba, Elcy
    De Aza, Antonio H.
    BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VIDRIO, 2016, 55 (01): : 1 - 12
  • [2] q Bone-Like Apatite-Forming Ability of Ca3(PO4)2-CaMg(SiO3)2 Ceramics in Simulated Body Fluid
    Carrodeguas, R. G.
    Cordoba, E.
    De Aza, A. H.
    De Aza, S.
    Pena, P.
    BIOCERAMICS 21, 2009, 396-398 : 103 - 106
1